Team:TU-Eindhoven

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Latest revision as of 12:52, 26 October 2013

Welcome to the homepage of the TU Eindhoven 2013 iGEM team.

We will create bacteria that can detect tumors
and visualize them on an MRI scan.
Mission Statement of the TU/e iGEM 2013 Team

Our Project
Visualizing tumors using bacteria? Find out what our project is all about!

Learn more...
Wetlab
Take a look at the results of the broad range of experiments performed this year.

Learn more...
Drylab
Various simulations were carried out to support the wetlab experiments.

Learn more...

True. False. Inconclusive.

Which Facts are Synthetic?

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-Welcome to the homepage of the 2013 iGEM team of the Eindhoven University of Technology.
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+===Welcome to the homepage of the TU Eindhoven 2013 iGEM team.===
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-==Project Description==
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-Within our project we aim to focus on a relatively new form of {{:Team:TU-Eindhoven/Template:Tooltip | text=MRI | tooltip=Magnetic Resonance Imaging }}: {{:Team:TU-Eindhoven/Template:Tooltip | text=CEST | tooltip=Chemical Exchange Saturation Transfer }} imaging. CEST imaging proteins contain hydrogen atoms which can be used to create the same image quality as when conventional heavy metals are used.
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-We will attempt to use E. coli K-12 strains to produce these proteins once the bacteria enters the body, allowing the E. coli to be our delivery system and production factory. Unique to our process is the injection of the protein producing bacteria into the patient, as well as the tumour targeting element of the bacteria.Tumours present a {{:Team:TU-Eindhoven/Template:Tooltip | text=hypoxic | tooltip=Low oxygen saturation }} environment, an attribute which allows them to be targeted by our bacteria. Furthermore, these hypoxic conditions will be the trigger for the production of our CEST proteins. This will ensure that MRI contrast is created where tumours are present, and also provides a good means of tumour targeting for drug delivery systems in the future. Once the CEST MRI images have been taken, the bacteria will be killed and eliminated from the body using our killing mechanism.
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-We also propose a second application of our CEST-MRI contrast agent, which is the use of it for tracking bacteria in bacterial infection studies.
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-In order to achieve the production of our bacteria based CEST MRI contrast agent, we must create a series of diverse models focusing on the different components of the MRI contrast agent production. These models will range from the selection of the most adequate proteins for CEST MRI to the behaviour of the FNR promotor and the bacterial killing mechanism.
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-In the lab an attempt will be made to produce the CEST MRI proteins, both aerobically as well as anaerobically. To Enable the anaerobic expression specialized promotors will be designed which will react to the changes in oxygen saturation and ultimately trigger the protein expression. Should protein expression be successful either aerobically or anaerobically then these proteins can be tested for the quality of their contrast in an MRI machine.
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 {{:Team:TU-Eindhoven/Template:FrontThumbnail | image=TU-Eindhoven_Images_MRIPromo.jpg | link=/Team:TU-Eindhoven/Wetlab | heading=Wetlab | text=Take a look at the results of the broad range of experiments performed this year. }}
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+<html><div class="thumbnail" style="background: url('https://static.igem.org/mediawiki/2013/2/2d/TU-Eindhoven_Images_Header4.jpg') repeat-x center top !important; height: 150px;"><center><div style="font-size: 48pt; line-height: 48pt; text-algin: center; margin-top: 20px; font-weight: bold; color: #555555;">True. False. Inconclusive.</div><div style="font-size: 48pt; line-height: 48pt; text-algin: center; margin-top: -48pt; font-weight: bold; color: #555555;"><span id="tue-sf-true" style="color: #008000; opacity: 0.0;">True.</span> <span id="tue-sf-false" style="color: #FF0000; opacity: 0.0;">False.</span> <span id="tue-sf-undecided" style="color: #0000FF; opacity: 0.0;">Inconclusive.</span></div><br /><a class="btn btn-info" target="_blank" href="http://syntheticfacts.tue.nl">Which Facts are Synthetic?</a></center></div></html>
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