Team:Hong Kong HKUST/Project

From 2013.igem.org

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<br><br><div id="desc">FAT BUSTER<br>Resistance to Diet-Induced Obesity with Synthetic  Glyoxylate Shunt<br><br>While low-fat diet and regular exercise are popular approaches to fight obesity, one easy alternative is simply to increase energy metabolism.  
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<br><br><div id="desc" class="center">FAT BUSTER<br>Resistance to Diet-Induced Obesity with Synthetic  Glyoxylate Shunt<br><br>While low-fat diet and regular exercise are popular approaches to fight obesity, one easy alternative is simply to increase energy metabolism.  
In terms of fat storage, conversion of carbohydrates or protein into fat uses ten times more calories of energy than simply storing fat in a fat cell. This brought us attention to one method of burning calories - increase energy expenditure by converting fat into glucose. However, mammals cannot convert fatty acids into carbohydrate due to lack of glyoxylate enzymes, while plants and bacteria can. We envision to introduce glyoxylate enzymes into mammalian cells and create an artificial futile cycle.
In terms of fat storage, conversion of carbohydrates or protein into fat uses ten times more calories of energy than simply storing fat in a fat cell. This brought us attention to one method of burning calories - increase energy expenditure by converting fat into glucose. However, mammals cannot convert fatty acids into carbohydrate due to lack of glyoxylate enzymes, while plants and bacteria can. We envision to introduce glyoxylate enzymes into mammalian cells and create an artificial futile cycle.

Revision as of 14:45, 12 September 2013