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Overview :

After we decided to use nanoparticles as our carrier, we had to find which kind of nanoparticles would suit our project the best. We first thought about polymers, but we needed something that could easily be degraded. So, we decided to use gelatin. It can be specifically degraded by enzymes. What's more, we found that many different kinds of gelatin nanoparticles had been made, with various loadings, such as proteins, organic molecules or DNA. We made our gelatin nanoparticles using a modified two-step desolvation method, and tried loading them with fluorescently labeled dextran and recombinant GFP. We also labeled the nanoparticles directly with a dye. What's more, all of them were biotinylated, so that they could be linked to bacteria expressing streptavidin on their surface.