Ganciclovir Distribution

Ganciclovir is the prodrug to kill the bacteria. See the principle of killing:(). The bacteria needs to be killed at a mild rate. So it is important to predict the concentration of ganciclovir in the body, especially in the tumor zone. In this part we used Physiologically based pharmacokinetic model

Killing Mechanism

The scheme of killing mechanism is shown below.

Pharmacokinetic Model

The pharmacokinetic model is a useful tool to predict drug concentrations in human tissues. The essence of pharmacokinetic model is the *compartmental method* and the *diffusion limitation*.

References