Team:Colombia Uniandes/Modeling

From 2013.igem.org

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For this project, to make the differential ecuations we consider the system proposed in the [https://2013.igem.org/Team:Colombia_Uniandes/Project project description ] and the table of symbols shown below.
For this project, to make the differential ecuations we consider the system proposed in the [https://2013.igem.org/Team:Colombia_Uniandes/Project project description ] and the table of symbols shown below.
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[[File:SymbolsGC.jpg|700px|thumb|center|'''Symbols used in the document and simulation''']]
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[[File:SymbolsGC.jpg|400px|thumb|center|'''Symbols used in the document and simulation''']]
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== Nickel removal system ==
== Nickel removal system ==
[[File:NickelConstruct.jpg|700px|thumb|center|'''Nickel removal system construct''']]
[[File:NickelConstruct.jpg|700px|thumb|center|'''Nickel removal system construct''']]

Revision as of 21:41, 17 July 2013

Diferential ecuations

We use the mathematical model to check if the design works, before starting to work at the lab. To develop this model the first step is the do the deterministic model, which is based in differential equations. This type of model describe the mean behaviour for each of the substances in the synthetic circuit over time. However, it does not take into account the probabilities involved in each of the events described, the population interactions and the noise of the system.

The deterministic model is based in the law of mass conservation and expresses the inputs and outputs of the system with expressions that use the law of mass action and known models like HIll's or Michaelis Menten.

Below are shown and explained the differential equations that allowed us to work in both projects:


Glucocorticoid sensor

For this project, to make the differential ecuations we consider the system proposed in the project description and the table of symbols shown below.

Symbols used in the document and simulation

Nickel removal system

Nickel removal system construct