"
Team:Evry
From 2013.igem.org
| Line 9: | Line 9: | ||
<p> | <p> | ||
This year we choose to develop a project which deals with hematologic diseases, which concerns more precisely diseases with an iron overload disorder. Among those type of diseases, there are the hereditary hemochromatosis and hemosiderosis. In the case of hereditary hemochromatosis, the iron overload disorder is a direct consequence of the disease. While in the hemosiderosis this consequence is due to a metabolic perturbation. | This year we choose to develop a project which deals with hematologic diseases, which concerns more precisely diseases with an iron overload disorder. Among those type of diseases, there are the hereditary hemochromatosis and hemosiderosis. In the case of hereditary hemochromatosis, the iron overload disorder is a direct consequence of the disease. While in the hemosiderosis this consequence is due to a metabolic perturbation. | ||
| - | < | + | </p> |
| + | <p> | ||
Today the iron overload can be treated by bloodletting in the case of the hemochromatosis but it cannot be used in the case of hemosiderosis because patients suffer of anaemia. In our project we want to solve this problem acting directly in the iron absorption source, in the intestines. | Today the iron overload can be treated by bloodletting in the case of the hemochromatosis but it cannot be used in the case of hemosiderosis because patients suffer of anaemia. In our project we want to solve this problem acting directly in the iron absorption source, in the intestines. | ||
| - | < | + | </p> |
| + | <p> | ||
Using the Ferric Uptake Regulation system, we engineered a bacterium giving it the ability to produce siderophores (iron chelator) in response of iron. In order to limit the iron overload in the patient, this bacterium would be placed in the intestines. | Using the Ferric Uptake Regulation system, we engineered a bacterium giving it the ability to produce siderophores (iron chelator) in response of iron. In order to limit the iron overload in the patient, this bacterium would be placed in the intestines. | ||
</p> | </p> | ||
Revision as of 16:08, 7 August 2013
Welcome to the Iron coli Project
Abstract
This year we choose to develop a project which deals with hematologic diseases, which concerns more precisely diseases with an iron overload disorder. Among those type of diseases, there are the hereditary hemochromatosis and hemosiderosis. In the case of hereditary hemochromatosis, the iron overload disorder is a direct consequence of the disease. While in the hemosiderosis this consequence is due to a metabolic perturbation.
Today the iron overload can be treated by bloodletting in the case of the hemochromatosis but it cannot be used in the case of hemosiderosis because patients suffer of anaemia. In our project we want to solve this problem acting directly in the iron absorption source, in the intestines.
Using the Ferric Uptake Regulation system, we engineered a bacterium giving it the ability to produce siderophores (iron chelator) in response of iron. In order to limit the iron overload in the patient, this bacterium would be placed in the intestines.
