"
Team:Evry
From 2013.igem.org
| Line 16: | Line 16: | ||
Using the Ferric Uptake Regulation (FUR) system to control siderophore (iron chelator) biosynthesis, we engineered a bacterium giving it the ability to produce these siderophores in response of iron. In order to limit the iron overload in the patient, this bacterium would be placed in the intestines. | Using the Ferric Uptake Regulation (FUR) system to control siderophore (iron chelator) biosynthesis, we engineered a bacterium giving it the ability to produce these siderophores in response of iron. In order to limit the iron overload in the patient, this bacterium would be placed in the intestines. | ||
</p> | </p> | ||
| + | |||
| + | |||
| + | |||
| + | <p>This year we choose to develop a project about hematologic diseases which implie iron overload disorder. We focus on hemosiderosis, heriditary or secondary (due to a metabolic perturbation). Nowadays, the iron overload can be treated by invasive method as blodletting, which cannot be used for anemic patient, or by transfusion of iron chelator which have lot of sides effect.</p> | ||
| + | <p> | ||
| + | Our project is to design a new treatment of hemosiderosis using engineered bacteria, to solve the overabsorption directly at the iron absorption source, in the intestines.</p> | ||
| + | <p> | ||
| + | Using the Ferric Uptake Regulation (FUR) system, naturally active in E.coli during iron starvation period, to control siderophore (iron chelator) byosynthesis, we design a bacterium able to produce these siderophores in response of hight iron concentration. Bacteria would be placed in capsule and ingest during a meal, and then could limit iron absorption by chelating iron on the duodenum. | ||
| + | </p> | ||
| + | <p> | ||
| + | As this treatment could have impact, positive or negative, on patient life, we model the possible effects of such a treatment on organism (and other truc de modelleux.) We also note down expert opinion to improve the safety and our treatment. | ||
| + | |||
| + | |||
<script type='text/javascript'>writeFooter()</script> | <script type='text/javascript'>writeFooter()</script> | ||
</html> | </html> | ||
Revision as of 09:36, 8 August 2013
Welcome to the Iron coli Project
Abstract
This year we choose to develop a project which deals with hematologic diseases. We focused specifically on diseases with an iron overload disorder. Among those type of diseases, we were interested in the hereditary hemochromatosis and hemosiderosis. In the case of hereditary hemochromatosis, the iron overload disorder is a direct consequence of this disease. While in the hemosiderosis the iron overload is due to a metabolic perturbation.
Today the iron overload can be treated by bloodletting in the case of the hemochromatosis but it cannot be used as a treatment of hemosiderosis because patients suffer of anaemia. In our project we want to solve this problem acting directly at the iron absorption source, in the intestines.
Using the Ferric Uptake Regulation (FUR) system to control siderophore (iron chelator) biosynthesis, we engineered a bacterium giving it the ability to produce these siderophores in response of iron. In order to limit the iron overload in the patient, this bacterium would be placed in the intestines.
This year we choose to develop a project about hematologic diseases which implie iron overload disorder. We focus on hemosiderosis, heriditary or secondary (due to a metabolic perturbation). Nowadays, the iron overload can be treated by invasive method as blodletting, which cannot be used for anemic patient, or by transfusion of iron chelator which have lot of sides effect.
Our project is to design a new treatment of hemosiderosis using engineered bacteria, to solve the overabsorption directly at the iron absorption source, in the intestines.
Using the Ferric Uptake Regulation (FUR) system, naturally active in E.coli during iron starvation period, to control siderophore (iron chelator) byosynthesis, we design a bacterium able to produce these siderophores in response of hight iron concentration. Bacteria would be placed in capsule and ingest during a meal, and then could limit iron absorption by chelating iron on the duodenum.
As this treatment could have impact, positive or negative, on patient life, we model the possible effects of such a treatment on organism (and other truc de modelleux.) We also note down expert opinion to improve the safety and our treatment.
