Team:Freiburg/Notebook/lab effector

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Abstract
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Effector Notebooks
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<b>Gene Regulation – Multiple Targets – Activation – Optogenetics – Repression – Inducibility – Epigenetics </b>
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<a href="https://2013.igem.org/Team:Freiburg/Notebook/lab_effector/krab"> Cas9-KRAB Notebook </a>
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<a href="https://2013.igem.org/Team:Freiburg/Notebook/lab_effector/vp16"> Cas9-VP16 Notebook </a>
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<p>Just imagine there was a tool that combined all these aspects of lab work. A tool, that was able to rule several genes at once; a tool that allowed highly specific gene modulation via stimulus induction; a tool that would be a new approach to gene regulation. </p>
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<p>This year’s Freiburg iGEM Team uses the prokaryotic CRISPR/Cas system to enable multiple endogenous gene regulation with minimal effort. The regulation is based on a protein-RNA-DNA interaction. Customizable RNAs function as a guide for our protein in order to target specific DNA sequences. By fusing effector domains to this protein, we aim at developing a tool for multiple and inducible gene activation and repression. Despite the system's prokaryotic origin, gene target sequences are adjustable for various organisms, offering a broad application variety of our tool. Due to its great potential, the CRISPR/Cas system has become of increasing importance in current research and can be implemented in a number of novel and interesting applications, such as gene therapy or tissue engineering. </p>
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<a href="https://2013.igem.org/Team:Freiburg/Notebook/lab_effector/g9a"> Cas9-G9A Notebook </a>
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Revision as of 20:20, 12 September 2013