Team:Freiburg/Notebook/lab effector

From 2013.igem.org

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Latest revision as of 05:07, 28 October 2013

Effector Notebooks

Activation

Epigenetics

Repression

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-<p class="first_order"><a href="https://2013.igem.org/Team:Freiburg/Notebook/lab_effector"> Effector </a></p>
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-<p class="second_order"> <a href="https://2013.igem.org/Team:Freiburg/Notebook/lab_repression">Repression </a> </p>
+<p class="second_order_note"> <a href="https://2013.igem.org/Team:Freiburg/Notebook/lab_epigenetics">Epigenetics </a> </p>
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 <p class="first_order"><a href="https://2013.igem.org/Team:Freiburg/Notebook/modeling"> Modeling </a></p>
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-<b>Gene Regulation – Multiple Targets – Activation – Optogenetics – Repression – Inducibility – Epigenetics </b>
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-<p>Just imagine there was a tool that combined all these aspects of lab work. A tool, that was able to rule several genes at once; a tool that allowed highly specific gene modulation via stimulus induction; a tool that would be a new approach to gene regulation. </p>
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-<p>This year’s Freiburg iGEM Team uses the prokaryotic CRISPR/Cas system to enable multiple endogenous gene regulation with minimal effort. The regulation is based on a protein-RNA-DNA interaction. Customizable RNAs function as a guide for our protein in order to target specific DNA sequences. By fusing effector domains to this protein, we aim at developing a tool for multiple and inducible gene activation and repression. Despite the system's prokaryotic origin, gene target sequences are adjustable for various organisms, offering a broad application variety of our tool. Due to its great potential, the CRISPR/Cas system has become of increasing importance in current research and can be implemented in a number of novel and interesting applications, such as gene therapy or tissue engineering. </p>
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+<a id="link" href="https://2013.igem.org/Team:Freiburg/Notebook/lab_epigenetics"> Epigenetics </a>
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+<a id="link" href="https://2013.igem.org/Team:Freiburg/Notebook/lab_repression"> Repression </a>
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