Team:GeorgiaTech

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Georgia Tech iGEM GT logo

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+<a href="https://2013.igem.org">
+<h2 style = "position:fixed; top:40px; right: 20%">iGEM Main Page</h2></a>
+<a href="https://2013.igem.org">
+       <img id = "igem" src = "https://static.igem.org/mediawiki/2013/4/46/Igem_qgem_logo.png" style = "width: 10%; position: fixed; top: 20px; right:10%" alt = "igem logo"></img></a>
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          <div style ="display:block">
-             <p id ="objective" style="display:none">
-                The objective for our project is ultimately to express human integrins on the surface of E.Coli cells.  By expressing
-                human integrins on bacteria cells, we can manipulate the cells to respond to specific stimuli in their environment. The
-                specific integrin we are trying to express on the E.Coli cell has the ability to bind to fibrinogen. If it is successfully placed
-                on the cell, the cell will be able to bind to fibrinogen, effectively coagulating or clotting blood. This has applications in the
-                medical field, where the integrin-containing E.Coli (BioBots, as we like to call them) can be administered as a topical solution
-                and prevent excessive bleeding on major surface wounds.  A bacteria’s ability to express integrins has other applications as
-                well. Since the bacteria will be able to send and receive signals to its environment, the bacteria can theoretically detect and
-                locate cancer cells, as well as any other specific cell or structure of concern. These novel bacterial robots will represent the
-                first prokaryotic use of heterodimeric integrins for a sensory function and will represent a platform that will enable future
-                “design” of integrins sensory function through molecular evolution techniques.
-            </p>
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          <div id ="menu" style ="display:none; position:absolute" ><p class =" textLarge">Menu</p></div>
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                  <li class="active">
                      <a href="https://2013.igem.org/Team:GeorgiaTech" style ="font-size:80px; padding-top:8px;padding-bottom:8px">
-                         <img src = "https://static.igem.org/mediawiki/2013/f/f0/GeorgiaTech_team.png" class = "smallLogo" alt ="GT iGEM logo"></img>Home
+                         <img src = "https://static.igem.org/mediawiki/2013/f/f0/GeorgiaTech_team.png" class = "smallLogo" alt ="GT iGEM logo"/>Home
                      </a>
                  </li>
+                <li><a href="https://2013.igem.org/Team:GeorgiaTech/Objective" style ="padding-top:8px;padding-bottom:8px">Objective</a></li>
                  <li><a href="https://2013.igem.org/Team:GeorgiaTech/Team" style ="padding-top:8px;padding-bottom:8px">Team</a></li>
-                 <li><a href="https://2013.igem.org/Team:GeorgiaTech/Project" style ="padding-top:8px;padding-bottom:8px">Project</a></li>
+                 <li><a href="https://2013.igem.org/Team:GeorgiaTech/Project" style ="padding-top:8px;padding-bottom:8px">Projects</a></li>
+                <li><a href="https://2013.igem.org/Team:GeorgiaTech/Protocol" style ="padding-top:8px;padding-bottom:8px">Protocols</a></li>
                  <li><a href="https://2013.igem.org/Team:GeorgiaTech/Parts" style ="padding-top:8px;padding-bottom:8px">Parts</a></li>
                  <li><a href="https://2013.igem.org/Team:GeorgiaTech/Safety" style ="padding-top:8px;padding-bottom:8px">Safety</a></li>
                  <li><a href="https://2013.igem.org/Team:GeorgiaTech/Attributions" style ="padding-top:8px;padding-bottom:8px">Attributions</a></li>
-                 <li><a href="https://2013.igem.org/Team:GeorgiaTech/Parts" style ="padding-top:8px;padding-bottom:8px">High School Project</a></li>
+                 <li><a href="https://2013.igem.org/Team:GeorgiaTech/Human_Practices" style ="padding-top:8px;padding-bottom:8px">Human Practices</a></li>
                  <li><a id ="return" href="#" style ="padding-top:8px;padding-bottom:8px">RETURN</a></li>
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-==Objective==
-===planned results and significance of work===
-The objective for our project is ultimately to express human integrins on the surface of E.Coli cells.  By expressing
-human integrins on bacteria cells, we can manipulate the cells to respond to specific stimuli in their environment. The
-specific integrin we are trying to express on the E.Coli cell has the ability to bind to fibrinogen. If it is successfully placed
-on the cell, the cell will be able to bind to fibrinogen, effectively coagulating or clotting blood. This has applications in the
-medical field, where the integrin-containing E.Coli (BioBots, as we like to call them) can be administered as a topical solution
-and prevent excessive bleeding on major surface wounds.  A bacteria’s ability to express integrins has other applications as
-well. Since the bacteria will be able to send and receive signals to its environment, the bacteria can theoretically detect and
-locate cancer cells, as well as any other specific cell or structure of concern. These novel bacterial robots will represent the
-first prokaryotic use of heterodimeric integrins for a sensory function and will represent a platform that will enable future
-“design” of integrins sensory function through molecular evolution techniques.
-==Background==
-===problem statement, previous work, and/or description of need===
-Cells perform their intended functions not individually but collectively by forming temporally evolving, three dimensional structures
-comprised of clusters of cells, and through active or passive cell-cell and cell-extracellular matrix (ECM) interactions.
-Thus the development of engineered, integrative cellular systems that self-heal and adapt their microstructure to a variety of stimuli
-in the surrounding microenvironment will revolutionize the way bioengineers design. The goals of EBICS is to address the grand challenge
-of engineering multi-cellular biological machines that have desired functionalities and can perform prescribed tasks.
-These machines consist of sensing, information processing, actuation, protein expression, and transport elements that can be
-effectively combined to create functional units. Fortunately, nature provides plenty of inspiration through similarly functioning
-organisms and systems.  It is therefore feasible to assume that artificial materials and organisms of the future will incorporate such
-naturally inspired designs. The imitation of the aforementioned functions will require development of systems similar to specialized cells in the
-various human tissues.  The GT iGEM team will work toward the lofty goal of developing of cells and/or extracellular vesicles
-(e.g. platelets) that display designer sensory-response behaviors.  In particular, small ‘smart’ biobots are an interesting
-avenue to duplicate the function of cells responsible for repair and adaptation.
-One of the tools that eukaryotic cells have at their disposal to detect their surroundings are heterodimeric sensor
-molecules present on the cell surface, known as integrins.  Not only do integrins receive and facilitate cellular integration
-of extracellular cues, but they also support inside-out signaling and thus can dynamically impact their microenvironment.
-As a consequence of integrin’s critical role in this cell-ECM “dynamic reciprocity”, they represent the ideal sensor to build
-into a biobot.  Synthetic biology applications are traditionally performed in the bacterial systems due to their availability,
-convenience, and speed. In order to complete our goal of expressing human integrins on the surface of bacterial cells,
-we will need a variety of lab and research materials necessary to experiment with the cells and eventually incorporate the
-integrins onto them. We will then need a way to test the effectiveness of the integrins on the cells. All funds given to us will
-help cover our lab material expenses.
-{|
-|-
-|align="center"|[[Team:GeorgiaTech | Team GeorgiaTech]]
-|-
-|}
-<!--- The Mission, Experiments --->
-{| style="color:#1b2c8a;background-color:#0c6;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="62%" align="center"
-!align="center"|[[Team:GeorgiaTech|Home]]
-!align="center"|[[Team:GeorgiaTech/Team|Team]]
-!align="center"|[https://igem.org/Team.cgi?year=2013&team_name=GeorgiaTech Official Team Profile]
-!align="center"|[[Team:GeorgiaTech/Project|Project]]
-!align="center"|[[Team:GeorgiaTech/Parts|Parts Submitted to the Registry]]
-!align="center"|[[Team:GeorgiaTech/Modeling|Modeling]]
-!align="center"|[[Team:GeorgiaTech/Notebook|Notebook]]
-!align="center"|[[Team:GeorgiaTech/Safety|Safety]]
-!align="center"|[[Team:GeorgiaTech/Attributions|Attributions]]
-|}