Team:Paris Bettencourt/Project/Overview

Using Escherichia coli as a model organism we are developing and testing approaches that could lead to eradication of tuberculosis. A drug screen aimed for a specific mycobacterial metabolic pathway, a phage sensor for detection of a specific antibiotic resistance, a TB-ception E. coli which could invade macrophages and kill mycobacteria, and finally a Trojan horse sRNA which could silence the production of antibiotic resistance proteins thus making antibiotic treatment more effective.