Team:Paris Bettencourt/Project/Overview

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FIGHT TUBERCULOSIS WITH MODERN WEAPONS

Using Escherichia coli as a model organism we are developing approaches that could lead to eradication of tuberculosis. A drug screen aimed for a specific mycobacterial metabolic pathway, a biosensor for detection of sequence specific antibiotic resistance, a synthetic E. coli which could invade macrophages and kill mycobacteria, and finally a phage carrying sRNA which silence the production of antibiotic resistance proteins thus making antibiotic treatment more effective.

Infiltrate

A more efficient treatment of TB should contain a drug which rapidly kills mycobacteria and a delivery system for such drug, which could enable the killing of mycobacteria inside the infected macrophages. In our system the rapid drug is Trehalose Dimycolate Hydrolase (TDMH), while the delivery system is LLO carrying strain of E. coli.

Centre for Research and Interdisciplinarity (CRI)
Faculty of Medicine Cochin Port-Royal, South wing, 2nd floor
Paris Descartes University
24, rue du Faubourg Saint Jacques
75014 Paris, France
+33 1 44 41 25 22/25
team2013@igem-paris.org
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