Team:Penn/Project2
From 2013.igem.org
(Difference between revisions)
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but the tools don’t exist to easily manipulate epigenetic patterns. We are developing a novel | but the tools don’t exist to easily manipulate epigenetic patterns. We are developing a novel | ||
fusion protein that enables site-specific methylation, which can repress promoter activity with | fusion protein that enables site-specific methylation, which can repress promoter activity with | ||
- | high precision. <div class="figure-wrap" style="float: center;"><img src="https://googledrive.com/host/0B4ZBZOYYKBzEdmZMalozd0pkSjg" style="height: 75px;"/> | + | high precision. <div class="figure-wrap" style="float: center;"><img src="https://googledrive.com/host/0B4ZBZOYYKBzEdmZMalozd0pkSjg" style="height: 75px; float: left;"/> |
- | <img src="https://googledrive.com/host/0B4ZBZOYYKBzEdlExOEgtVlZYYUU" style="height: 75px; float: | + | <img src="https://googledrive.com/host/0B4ZBZOYYKBzEdlExOEgtVlZYYUU" style="height: 75px; float: left;"/></div>In coming years, this fusion protein could become a powerful tool for epigenetics |
researchers looking to perform on/off studies in the vein of classical genetics, as well as an | researchers looking to perform on/off studies in the vein of classical genetics, as well as an | ||
orthogonal mode of repressing constitutive promoters for bacterial synthetic biologists. | orthogonal mode of repressing constitutive promoters for bacterial synthetic biologists. | ||
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levels in many insofar-untreatable epigenetic diseases.</p> | levels in many insofar-untreatable epigenetic diseases.</p> | ||
<img src="https://googledrive.com/host/0B4ZBZOYYKBzEMzM5dWpRQWNvb1k" style="height: 60px; display: inline; float: right;"/> | <img src="https://googledrive.com/host/0B4ZBZOYYKBzEMzM5dWpRQWNvb1k" style="height: 60px; display: inline; float: right;"/> | ||
- | <img src="https://googledrive.com/host/0B4ZBZOYYKBzEek95VVUyMkltSHc" style="height: 60px; "/> | + | <img src="https://googledrive.com/host/0B4ZBZOYYKBzEek95VVUyMkltSHc" style="height: 60px; float: right;"/> |
</div> | </div> | ||
Revision as of 00:29, 11 August 2013
Abstract
The code of life is much more than a sequence of A's, G's, C's and T's; a suite of epigenetic mechanisms, ranging from chromatin remodeling to non-coding RNAs, affect gene expression and cellular function.
Synthetic biologists and geneticists are accustomed to turning genes on and off at will, but the tools don’t exist to easily manipulate epigenetic patterns. We are developing a novel fusion protein that enables site-specific methylation, which can repress promoter activity with high precision.