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Team:SydneyUni Australia/Modelling Intro
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== '''Introduction'''== | == '''Introduction'''== | ||
| - | A pharmacokinetic model was constructed in order to determine the intracellular concentration of the metabolites as a function of time and determine the rate at which DCA is removed from solution. The synthetic metabolic pathway involves four introduced enzymes which converts the substrate 1,2-dichloroethane (DCA) into the end product glycolate through 3 metabolic intermediates. The concentration of each metabolic species over time was modelled through a system of ordinary differential equations (ODE) where Michaelis-Menton (MM) equations were used to model the kinetics of each enzyme of our constructed metabolic pathway. | + | <div align="justify">A pharmacokinetic model was constructed in order to determine the intracellular concentration of the metabolites as a function of time and determine the rate at which DCA is removed from solution. The synthetic metabolic pathway involves four introduced enzymes which converts the substrate 1,2-dichloroethane (DCA) into the end product glycolate through 3 metabolic intermediates. The concentration of each metabolic species over time was modelled through a system of ordinary differential equations (ODE) where Michaelis-Menton (MM) equations were used to model the kinetics of each enzyme of our constructed metabolic pathway. </div> |
{{Team:SydneyUni_Australia/Footer}} | {{Team:SydneyUni_Australia/Footer}} | ||
Revision as of 13:54, 27 September 2013
Introduction
A pharmacokinetic model was constructed in order to determine the intracellular concentration of the metabolites as a function of time and determine the rate at which DCA is removed from solution. The synthetic metabolic pathway involves four introduced enzymes which converts the substrate 1,2-dichloroethane (DCA) into the end product glycolate through 3 metabolic intermediates. The concentration of each metabolic species over time was modelled through a system of ordinary differential equations (ODE) where Michaelis-Menton (MM) equations were used to model the kinetics of each enzyme of our constructed metabolic pathway.
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