Team:TU-Delft/BandAidSelection

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Revision as of 09:23, 24 September 2013 by Dimitra (Talk | contribs)


Band Aid as a Final application





The main focus of our project is to engineer E.coli that can detect MRSA in order to locally produce and deliver antimicrobial peptides against it.This project may have implications to society, especially if the mechanism is put into a real application. This fact made as think of the application that would be the best for our project and we came out with the band aid idea!

By using the band aid, the safety of the real application can be ensured in numerous ways. First of all, the complete system is enclosed into the band aid and in that way it can be located on the wound without the existence of direct intact with the patience. Apart from this, by carefully selecting the band aid characteristics based on specific criteria the selective input/output of substances can also be assured. Specifically, the band aid pore size is set to a diameter of 0.22 μm in order to be impossible for the E.coli to escape from the band aid and to infect the patient but to be feasible for both the AIPs and the peptide to pass through. Moreover, we also chose membranes that cannot break easily in order to avoid the infection of patient in case that something goes wrong. Last but not least, the band aids were selected in such a way so as not to be toxic or become toxic for E.coli. Because if that is teh case, then the complete system will fail and the patient will also be infected.