Team:UCL/Project/Circuit

From 2013.igem.org

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<p class="minor_title">IGEM: Intelligently Genetically Engineered Microglia</p>
<p class="minor_title">IGEM: Intelligently Genetically Engineered Microglia</p>
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Our ambitious project [internal link to PROJECT main sub-page]  concerns bringing synthetic biology to the brain in order to try a novel approach to tackling Alzheimer’s Disease [internal link to Alzheimer’s disease]. Microglia [internal link to microglia] are mobile brain cells, making them an ideal chassis [internal link to chassis]. To do this, our proposed treatment would involve extracting microglia from a patient, or using a specially bred immortalised line of human microglia, to avoid rejection, and transfecting it with our new genetic circuit. Implantation into the brain could be performed surgically or using a viral vector - but in order to better control the numbers of genetically engineered microglia (GEM) in the brain micro-neurosurgery may prove best. Our circuit is designed to detect [internal link to detection] amyloid plaques [internal link to neuropathology], attract other microglia, degrade [internal link to degradation] the plaques, reduce [internal link to future directions] neuroinflammation and support [internal link to future direction] dying neurons. Theoretically [internal link to neuropathology], this should halt the progression of Alzheimer’s disease and could lead to other forms of neuro-genetic engineering [internal link to Human Practice main sub-page].  
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Our <a href="http://2013.igem.org/Team:UCL/Project" target="_blank">ambitious project</a> concerns bringing synthetic biology to the brain in order to try a novel approach to tackling <a href="http://2013.igem.org/Team:UCL/Background/Alzheimers" target="_blank">Alzheimer’s Disease (AD)</a>. <a href="http://2013.igem.org/Team:UCL/Background/Microglia" target="_blank">Microglia</a> are mobile brain cells, making them an ideal <a href="http://2013.igem.org/Team:UCL/Project/Chassis" target="_blank">chassis</a>. To do this, our proposed treatment would involve extracting microglia from a patient, or using a specially bred immortalised line of human microglia, to avoid rejection, and transfecting it with our new genetic circuit. Implantation into the brain could be performed surgically or using a viral vector - but in order to better control the numbers of genetically engineered microglia (GEM) in the brain micro-neurosurgery may prove best. Our circuit is designed to detect <a href="http://2013.igem.org/Team:UCL/Project/Detection" target="_blank">detect</a> <a href="http://2013.igem.org/Team:UCL/Background/Neuropathology" target="_blank">amyloid plaques</a>, attract other microglia, <a href="http://2013.igem.org/Team:UCL/Project/Degradation" target="_blank">degrade</a> the plaques, <a href="http://2013.igem.org/Team:UCL/Project/Developments" target="_blank">reduce neuroinflammation and support </a> dying neurons. <a href="http://2013.igem.org/Team:UCL/Background/Neuropathology" target="_blank">Theoretically</a>, this should halt the progression of Alzheimer’s disease and could lead to other forms of <a href="http://2013.igem.org/Team:UCL/Practice" target="_blank">neuro-genetic engineering</a>.
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Revision as of 15:34, 4 September 2013

CIRCUIT OVERVIEW

IGEM: Intelligently Genetically Engineered Microglia

Our ambitious project concerns bringing synthetic biology to the brain in order to try a novel approach to tackling Alzheimer’s Disease (AD). Microglia are mobile brain cells, making them an ideal chassis. To do this, our proposed treatment would involve extracting microglia from a patient, or using a specially bred immortalised line of human microglia, to avoid rejection, and transfecting it with our new genetic circuit. Implantation into the brain could be performed surgically or using a viral vector - but in order to better control the numbers of genetically engineered microglia (GEM) in the brain micro-neurosurgery may prove best. Our circuit is designed to detect detect amyloid plaques, attract other microglia, degrade the plaques, reduce neuroinflammation and support dying neurons. Theoretically, this should halt the progression of Alzheimer’s disease and could lead to other forms of neuro-genetic engineering.