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Cellular Lead Sensor

About 40% of the world does not have access to clean water. Lead is a major contaminant worldwide. In the US alone, over 1 million children ages 1 through 5 have elevated levels of lead in their blood. Current lead detection systems are expensive and require lab analysis. Home lead testing kits are inaccurate and only detect lead at very high levels. We have created a genetic circuit in E Coli that responds to lead. The promoter and lead binding protein we use are ten times more selective for lead than for other similar heavy metals. We have also incorporated a genetic amplifier into our circuit to allow us to detect fairly low concentrations of lead.

Tristable Switch

The Tri-Stable Toggle Switch represents a continuation on the theme of the Toggle Switch begun by Gardner, et al to produce stable outputs in response to transient inputs. Applications such as a memory circuit and a drug delivery system are a few suggestions, but perhaps the most promising innovation lies in the design process. Our novel approach to the Tri-Stable Switch development is founded on quantitative principles, pioneering a technique to remove the guesswork from designing and debugging biological systems.

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Brown University students love the Brown iGEM Booth at the Student Activities Fair!


Brown iGEM visits Pfizer HQ in Groton, Conneticut


Nanodrop donates ND-1000 Spectrophotometer and ND-3300 Fluorospectrophotometer to Brown iGEM


Brown iGEM Team presents its August Update to faculty and friends


Nanodrop it like it's hot!


iGEM 2007 Meetup. Teams from MIT, BU, McGill, and Cold Spring Harbor presented their progress to each other and discussed the future of Synthetic Biology.


Brown iGEM presents summer research at the Brown University UTRA (Undergraduate Research) Symposium


Deepa and Tito gave a presentation to Brown Summer students and discussed the applications of synthetic biology


Brown iGEM presents June Update to faculty and friends of iGEM


The iGEM Team met up with Jody Hall's Biotechnology class on July 3rd. Afterwards we toured the lab and discussed the ethics of synthetic biology.


Brown iGEM presents June Update to Pfizer Team and Brown community


$25,000 grant from Pfizer for equipment purchases


Labnet sponsors Brown iGEM with vortex mixers, a microcentrifuge, pipettes, and autopipettes.

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