Team:Hong Kong HKUST/test17

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  • The fundamental cause of obesity is an energy imbalance between calories consumed and expended. To increase expenditure of fatty acids (calories), HKUST 2013 Team aims to introduce glyoxylate shunt as an artificial futile cycle in HepG2 cell.

  • Part 1 Sense Fatty Acids: We investigated four different sensing mechanisms using: 1) fatty acid metabolism regulator protein (FadR), 2) peroxisome proliferator-activated receptor-alpha (PPAR-alpha) 3) liver- fatty acid binding protein (FABP1) and 4) binding immunoglobulin protein, HSP5 or glucose regulated protein (GRP78). The four sensing mechanisms were measured and compared.










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