Team:Carnegie Mellon/Modeling

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If you choose to include a '''Modeling''' page, please write about your modeling adventures here.  This is not necessary but it may be a nice list to include.
If you choose to include a '''Modeling''' page, please write about your modeling adventures here.  This is not necessary but it may be a nice list to include.
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'''Intracellular model'''
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The intracellular model attempts to simulate the synthesis and action of
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KillerRed. It includes:
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mRNA synthesis and degradation
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KillerRed synthesis, maturation, and degradation
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KillerRed states: singlet, singlet excited, triplet excited, and deactivated
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Superoxide production (by KillerRed)
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Superoxide elimination (by superoxide dismutase)
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Parameters:
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mRNA synthesis: adapted from Kennell and Riezman 1977.
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mRNA degradation: Bernstein, Lin, Cohen, and Lin-Chao 2002.
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KillerRed synthesis: from Kennell and Riezman 1977 and our own fluorescence data
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Superoxide production: adapted from Tsien and Waggoner 1995; Song, Hennink, Young, and Tanke 1995; and our own fluorescence data.

Revision as of 19:09, 26 September 2013


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If you choose to include a Modeling page, please write about your modeling adventures here. This is not necessary but it may be a nice list to include.


Intracellular model

The intracellular model attempts to simulate the synthesis and action of

KillerRed. It includes:

mRNA synthesis and degradation KillerRed synthesis, maturation, and degradation KillerRed states: singlet, singlet excited, triplet excited, and deactivated Superoxide production (by KillerRed) Superoxide elimination (by superoxide dismutase)

Parameters:

mRNA synthesis: adapted from Kennell and Riezman 1977. mRNA degradation: Bernstein, Lin, Cohen, and Lin-Chao 2002. KillerRed synthesis: from Kennell and Riezman 1977 and our own fluorescence data Superoxide production: adapted from Tsien and Waggoner 1995; Song, Hennink, Young, and Tanke 1995; and our own fluorescence data.

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