Team:ITB Indonesia

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<h1>Our Project Description</h1>
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High levels of aflatoxin contamination of foods are found in many developing countries around the world. Aflatoxins are known to be mutagenic and carcinogenic, therefore human exposure to aflatoxin would lead to an increased risk of hepatocellular carcinoma (liver cancer). One in every four liver cancers in Indonesia are induced by aflatoxin B1 exposure. Nowadays, aflatoxin exposure is not only a serious problem for human health, but it could also become a serious threat in terms of food security issue of a country. ITB-Indonesia team for iGEM 2013 focuses on designing a whole cell biosensor for aflatoxin B1 detection in foods. The biosensor uses Escherichia coli as the chassis to build a genetic circuit using SOS response system to detect DNA damage caused by aflatoxin B1-oxide attack. The SOS response promoter is followed by a reporter gene coding a chromoprotein, therefore the concentration of aflatoxin B1 in food samples could be easily detected by the color change of the bacteria. For the ease of usage, we will design a syringe shaped device with our whole cell biosensor in it. This device would allow aflatoxin B1 to enter the device, but would not permit the cells to leave the device.  
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<p><a href="https://2013.igem.org/Team:ITB_Indonesia/BehindTheScene/DangerAflatoxin">How Dangerous Aflatoxin for Our Bodies?</a></p>
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<p><a href="https://2013.igem.org/Team:ITB_Indonesia/BehindTheScene/AflatoxinWholeCellBiosensor">Aflatoxin Whole Cell Biosensor : Towards Indonesian Food Security</a></p>
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<h2 class="title">How Dangerous Aflatoxin for Our Bodies?</h2>
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<img src="https://static.igem.org/mediawiki/igem.org/b/bf/ITB_Indonesia-sample1.jpg" alt=""/>
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Aflatoxins are carcinogenic and mutagenic, heat stable
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    (237-289&deg;C), and can accumulate through the food chain.  
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The presence of aflatoxins especially aflatoxin B1 on 
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food such as peanuts...
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</p>
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<div class="readmore">
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<a href="https://2013.igem.org/Team:ITB_Indonesia/BehindTheScene/DangerAflatoxin">Readmore</a>
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<h2 class="title">Aflatoxin Whole Cell Biosensor : Towards Indonesian Food Security</h2>
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<img src="https://static.igem.org/mediawiki/igem.org/f/f9/ITB_Indonesia-sample2.jpg" alt=""/>
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Not only for our health, Aflatoxin exposure can become  
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serious problems for economics and food security in  
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certain developing countries. Legumes is still an
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alternative staple food after rice and tubers...
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</p>
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<div class="readmore">
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<a href="https://2013.igem.org/Team:ITB_Indonesia/BehindTheScene/AflatoxinWholeCellBiosensor">Readmore</a>
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!align="center"|[[Team:ITB_Indonesia|Home]]
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!align="center"|[[Team:ITB_Indonesia/Team|Team]]
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<h2 class="title">Why Must be Whole Cells Biosensor ?</h2>
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!align="center"|[https://igem.org/Team.cgi?year=2013&team_name=ITB_Indonesia Official Team Profile]
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!align="center"|[[Team:ITB_Indonesia/Project|Project]]
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!align="center"|[[Team:ITB_Indonesia/Parts|Parts Submitted to the Registry]]
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<img src="https://static.igem.org/mediawiki/igem.org/f/f1/ITB_Indonesia-sample3.jpg" alt=""/>
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!align="center"|[[Team:ITB_Indonesia/Modeling|Modeling]]
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!align="center"|[[Team:ITB_Indonesia/Notebook|Notebook]]
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Accuracy and rapidity in monitoring toxin compounds, pollutants,
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!align="center"|[[Team:ITB_Indonesia/Safety|Safety]]
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or the presence of a pathogen in the environment became an
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!align="center"|[[Team:ITB_Indonesia/Attributions|Attributions]]
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important point from a measuring device (sensor). In the process
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!align="center"|[[Team:ITB_Indonesia/Riandy|About Riandy]]
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of monitoring a toxin...
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<a href="https://2013.igem.org/Team:ITB_Indonesia/BehindTheScene/WhyWholeCellBiosensor">Readmore</a>
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<h2 class="title">Aflatoxin Whole Biosensor Safetiness</h2>
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<img src="https://static.igem.org/mediawiki/igem.org/8/80/ITB_Indonesia-Sample4.jpg" alt=""/>
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The presence  a living cell as biosensor will automatically regulate
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the introduction of a critical environmental point for a biosensor.
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So a whole cell biosensor is more prefered and more advantageous as
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biosensor device...
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</p>
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<div class="readmore">
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<a href="https://2013.igem.org/Team:ITB_Indonesia/Safety">Readmore</a>
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Latest revision as of 01:56, 28 September 2013

How Dangerous Aflatoxin for Our Bodies?

Aflatoxins are carcinogenic and mutagenic, heat stable (237-289°C), and can accumulate through the food chain. The presence of aflatoxins especially aflatoxin B1 on food such as peanuts...

Readmore

Aflatoxin Whole Cell Biosensor : Towards Indonesian Food Security

Not only for our health, Aflatoxin exposure can become serious problems for economics and food security in certain developing countries. Legumes is still an alternative staple food after rice and tubers...

Readmore

Why Must be Whole Cells Biosensor ?

Accuracy and rapidity in monitoring toxin compounds, pollutants, or the presence of a pathogen in the environment became an important point from a measuring device (sensor). In the process of monitoring a toxin...

Readmore

Aflatoxin Whole Biosensor Safetiness

The presence a living cell as biosensor will automatically regulate the introduction of a critical environmental point for a biosensor. So a whole cell biosensor is more prefered and more advantageous as biosensor device...

Readmore

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