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Team:Leeds
From 2013.igem.org
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| - | {{Team:Leeds_layout|HeaderImage=[[File:Leeds_HomepageHead.png|825px|frameless]]|Header=Welcome to the Leeds Wiki!|content= | + | {{Team:Leeds_layout|HeaderParky=</div>[[File:Leeds_ParkyPanoram.png|150px|link=|frameless]]<div>|HeaderImage=[[File:Leeds_HomepageHead.png|825px|link=|frameless]]|Header=Welcome to the Leeds Wiki!|content= |
[[File:Leeds sooperheader3.png|center|700px|awesome looking header|link=|frameless]] | [[File:Leeds sooperheader3.png|center|700px|awesome looking header|link=|frameless]] | ||
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==The Leeds 2013 iGEM team== | ==The Leeds 2013 iGEM team== | ||
[[File:Leeds_Map.png|300px|right|The Kings in the North|link=http://maps.google.co.uk/maps?q=Leeds+map&oe=utf-8&client=firefox-a&ie=UTF-8&ei=VHDuUci7J7CT0AWYoYCQDg&ved=0CAoQ_AUoAg|frameless]] | [[File:Leeds_Map.png|300px|right|The Kings in the North|link=http://maps.google.co.uk/maps?q=Leeds+map&oe=utf-8&client=firefox-a&ie=UTF-8&ei=VHDuUci7J7CT0AWYoYCQDg&ved=0CAoQ_AUoAg|frameless]] | ||
| - | We are the Leeds 2013 iGEM team, | + | We are the Leeds 2013 iGEM team, a group of undergrads from various courses at the University of Leeds, all with a passion for synthetic biology! |
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Leeds is a city in West Yorkshire, in the North of England. It has strong historical ties to the wool industry, and is famous for the Tetley brand of bitter ale. | Leeds is a city in West Yorkshire, in the North of England. It has strong historical ties to the wool industry, and is famous for the Tetley brand of bitter ale. | ||
Latest revision as of 03:52, 5 October 2013
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 |  A biological system designed to detect the presence of pathogens in water samples Micro-Beagle is a novel reporter system for E-coli that, as an iGEM first, has been designed to dynamically detect arbitrary target solids (including other cells) through a mechanism activated by cell surface binding. Micro-Beagle was initially developed to address the need for a low cost, energy efficient and robust tool to be used to assess the effectiveness of current water purification systems. As the Micro-Beagle is intended to operate at a low cost it is ideal for use in low-income areas where the testing of water purification techniques cannot be maintained at an acceptable frequency. Micro-Beagle is designed to also be a modular system, utilising Ice Nucleation Protein to express and position target-binding peptides on the cell surface. Target binding induces membrane stress that activates the Cpx signalling pathway, and Micro-Beagle thus utilises a promoter from this pathway (pCpxR) to initiate expression of a reporter protein, such as GFP. As a proof of concept, we have used silica beads as a model diagnostic target (a pathogen surrogate) and the silica-binding “Si4” sequence as the target-binding peptide. We foresee Micro-Beagle being adapted for both the detection of waterborne pathogens and a variety of other diagnostic applications, and we envision future multisensor Micro-Beagles in which diverse pathogens can be simultaneously and quantitatively measured from a single water sample.
The Leeds 2013 iGEM team We are the Leeds 2013 iGEM team, a group of undergrads from various courses at the University of Leeds, all with a passion for synthetic biology!
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