Team:UCL

From 2013.igem.org

(Difference between revisions)
(Undo revision 294413 by Kckiew (talk))
 
(15 intermediate revisions not shown)
Line 10: Line 10:
<script>
<script>
-
var word1 = "HOME";
+
var word1 = "UCL iGEM";
-
var word2 = "PAGE";
+
var word2 = "2013";
 +
</script>
 +
 
 +
<script>
 +
 
 +
var x=0;
 +
 
 +
//doc
 +
$(document).ready(function(){
 +
  $("#doc").mouseover(function(){
 +
    //$("#pic_doc").stop().fadeIn();
 +
    $("#pic_doc").fadeIn(x);
 +
  });
 +
  $("#doc").mouseout(function(){
 +
    $("#pic_doc").fadeOut(x);
 +
  });
 +
});
 +
//micro
 +
$(document).ready(function(){
 +
  $("#micro").mouseover(function(){
 +
    //$("#pic_micro").stop().fadeIn();
 +
    $("#pic_micro").fadeIn(x);
 +
  });
 +
  $("#micro").mouseout(function(){
 +
    $("#pic_micro").fadeOut(x);
 +
  });
 +
});
 +
//creative
 +
$(document).ready(function(){
 +
  $("#creative").mouseover(function(){
 +
    //$("#pic_creative").stop().fadeIn();
 +
    $("#pic_creative").fadeIn(x);
 +
  });
 +
  $("#creative").mouseout(function(){
 +
    $("#pic_creative").fadeOut(x);
 +
  });
 +
});
 +
//model
 +
$(document).ready(function(){
 +
  $("#model").mouseover(function(){
 +
    //$("#pic_model").stop().fadeIn();
 +
    $("#pic_model").fadeIn(x);
 +
  });
 +
  $("#model").mouseout(function(){
 +
    $("#pic_model").fadeOut(x);
 +
  });
 +
});
 +
//circuit
 +
$(document).ready(function(){
 +
  $("#circuit1").mouseover(function(){
 +
    //$("#pic_circuit").stop().fadeIn();
 +
    $("#pic_circuit").fadeIn(x);
 +
  });
 +
  $("#circuit1").mouseout(function(){
 +
    $("#pic_circuit").fadeOut(x);
 +
  });
 +
});
 +
$(document).ready(function(){
 +
  $("#circuit2").mouseover(function(){
 +
    //$("#pic_circuit").stop().fadeIn();
 +
    $("#pic_circuit").fadeIn(x);
 +
  });
 +
  $("#circuit2").mouseout(function(){
 +
    $("#pic_circuit").fadeOut(x);
 +
  });
 +
});
 +
//neuro
 +
$(document).ready(function(){
 +
  $("#neuro1").mouseover(function(){
 +
    //$("#pic_neuro").stop().fadeIn();
 +
    $("#pic_neuro").fadeIn(x);
 +
  });
 +
  $("#neuro1").mouseout(function(){
 +
    $("#pic_neuro").fadeOut(x);
 +
  });
 +
});
 +
$(document).ready(function(){
 +
  $("#neuro2").mouseover(function(){
 +
    //$("#pic_neuro").stop().fadeIn();
 +
    $("#pic_neuro").fadeIn(x);
 +
  });
 +
  $("#neuro2").mouseout(function(){
 +
    $("#pic_neuro").fadeOut(x);
 +
  });
 +
});
 +
//sunshine
 +
$(document).ready(function(){
 +
  $("#sunshine1").mouseover(function(){
 +
    //$("#pic_sunshine").stop().fadeIn();
 +
    $("#pic_sunshine").fadeIn(x);
 +
  });
 +
  $("#sunshine1").mouseout(function(){
 +
    $("#pic_sunshine").fadeOut(x);
 +
  });
 +
});
 +
$(document).ready(function(){
 +
  $("#sunshine2").mouseover(function(){
 +
    //$("#pic_sunshine").stop().fadeIn();
 +
    $("#pic_sunshine").fadeIn(x);
 +
  });
 +
  $("#sunshine2").mouseout(function(){
 +
    $("#pic_sunshine").fadeOut(x);
 +
  });
 +
});
 +
$(document).ready(function(){
 +
  $("#sunshine3").mouseover(function(){
 +
    //$("#pic_sunshine").stop().fadeIn();
 +
    $("#pic_sunshine").fadeIn(x);
 +
  });
 +
  $("#sunshine3").mouseout(function(){
 +
    $("#pic_sunshine").fadeOut(x);
 +
  });
 +
});
 +
$(document).ready(function(){
 +
  $("#sunshine4").mouseover(function(){
 +
    //$("#pic_sunshine").stop().fadeIn();
 +
    $("#pic_sunshine").fadeIn(x);
 +
  });
 +
  $("#sunshine4").mouseout(function(){
 +
    $("#pic_sunshine").fadeOut(x);
 +
  });
 +
});
 +
 
 +
 
</script>
</script>
Line 39: Line 162:
<div id="container">
<div id="container">
-
<!-- START CONTENT ---------------------------------------------------------------------------------------------------->
 
-
<div class="gap">
 
-
</div>
 
-
<div class="row_large">
 
-
<div class="col_left">
+
<!-- START CONTENT ---------------------------------------------------------------------------------------------------->
-
 
+
<div id="artwork">
-
                <p class="major_title">SPOTLESS MIND</p>
+
<div id="pic_doc"><a href="https://2013.igem.org/Team:UCL/Practice/Documentary"></a></div>
-
+
<div id="pic_micro"><a href="https://2013.igem.org/Team:UCL/Background/Microglia"></a></div>
-
<p class="minor_title">Team Abstract</p>
+
<div id="pic_creative"><a href="https://2013.igem.org/Team:UCL/Practice/Creative"></a></div>
-
+
<div id="pic_model"><a href="https://2013.igem.org/Team:UCL/Modeling"></a></div>
-
<p class="body_text">
+
<div id="pic_circuit"><a href="https://2013.igem.org/Team:UCL/Project/Circuit"></a></div>
-
This year, the UCL iGEM team is taking a radical new step with synthetic biology. We intend to explore the potential application genetic engineering techniques on the brain, because it is the site of some of the most subtle, and many of the most devastating diseases known to medicine.</p>
+
<div id="pic_neuro"><a href="https://2013.igem.org/Team:UCL/Background/Neuropathology"></a></div>
-
<p class="body_text">
+
<div id="pic_sunshine"><a href="https://2013.igem.org/Team:UCL/Memories"></a></div>
-
We have devised a genetic circuit for transfecting into a novel chassis for iGEM that is rarely engineered in research - microglial cells, the resident immune cells of the brain. The circuit aims to boost the ability of the microglial cells to break down senile plaques, which are associated with the onset and progression of Alzheimer’s Disease, as well as to protect neurons under threat from these plaques and from inflammation. Alzheimer’s Disease is a neurodegenerative disease that is characterised by the loss of recent memory and intellectual functions. Late stages of the disease often see patients bedridden, mute and incontinent. It is a horrific condition for which a genetic engineering response is both pertinent and somewhat disconcerting. Therefore, we also delve into the neuroethics of the potential progression of synthetic biology in neuroscience.</p>
+
-
</div>
+
-
 
+
<div id="doc"><a href="https://2013.igem.org/Team:UCL/Practice/Documentary"></a></div>
-
 
+
<div id="micro"><a href="https://2013.igem.org/Team:UCL/Background/Microglia"></a></div>
-
<div class="col_right">
+
<div id="creative"><a href="https://2013.igem.org/Team:UCL/Practice/Creative"></a></div>
-
<a href="https://static.igem.org/mediawiki/2013/7/7f/Homepage_poster.png" data-lightbox="image-1" title="UCL iGEM poster">
+
<div id="model"><a href="https://2013.igem.org/Team:UCL/Modeling"></a></div>
-
<img src="https://static.igem.org/mediawiki/2013/7/7f/Homepage_poster.png">
+
-
</a>
+
<div id="circuit1"><a href="https://2013.igem.org/Team:UCL/Project/Circuit"></a></div>
 +
<div id="circuit2"><a href="https://2013.igem.org/Team:UCL/Project/Circuit"></a></div>
 +
 +
<div id="neuro1"><a href="https://2013.igem.org/Team:UCL/Background/Neuropathology"></a></div>
 +
<div id="neuro2"><a href="https://2013.igem.org/Team:UCL/Background/Neuropathology"></a></div>
 +
 +
<div id="sunshine1"><a href="https://2013.igem.org/Team:UCL/Memories"></a></div>
 +
<div id="sunshine2"><a href="https://2013.igem.org/Team:UCL/Memories"></a></div>
 +
<div id="sunshine3"><a href="https://2013.igem.org/Team:UCL/Memories"></a></div>
 +
<div id="sunshine4"><a href="https://2013.igem.org/Team:UCL/Memories"></a></div>
</div>
</div>
-
 
-
+
<div class="full_page">
-
</div>
+
<p class="major_title">IGEM: INTELLIGENTLY GENETICALLY ENGINEERED MICROGLIA</p>
-
 
+
<p class="minor_title">Synthetic Biology Fights Alzheimer's Disease</p>
-
<div class="gap">
+
-
</div>
+
-
 
+
-
<div class="row_small">
+
-
+
-
<div class="col_1" style="background-image:url('https://static.igem.org/mediawiki/2013/4/4b/Img1.png');">
+
-
</div>
+
-
+
-
<div class="col_1">
+
-
+
-
                <p class="minor_title">Aims</p>
+
-
+
-
<p class="body_text">This year, the UCL iGEM team is taking a radical new step with synthetic biology. We intend to explore the potential application genetic engineering techniques on the brain, because it is the site of some of the most subtle, and many of the most devastating diseases known to medicine.</p>
+
-
+
-
</div>
+
-
+
-
<div class="col_1" style="background-image:url('https://static.igem.org/mediawiki/2013/a/a9/Img2.png');">
+
-
</div>
+
-
+
-
<div class="col_2">
+
-
+
-
<p class="minor_title">Spotless Mind</p>
+
-
+
-
<p class="body_text">How happy is the blameless vestal's lot! / The world forgetting, by the world forgot. / Eternal sunshine of the spotless mind! / Each pray'r accepted, and each wish resign'd...</p>
+
-
<p class="citation_text"> - Alexander Pope, Eloisa to Abelard</p>
+
-
</div>
+
-
+
-
</div>
+
-
 
+
-
<div class="gap">
+
-
</div>
+
-
 
+
-
</div>
+
 +
<p class="abstract_text" style="color:#404040;">
 +
This year, the UCL iGEM team is taking a radical new step with synthetic biology. We intend to explore the potential application genetic engineering techniques on the brain, because it is the site of some of the most subtle, and many of the most devastating medical conditions. Alzheimer’s Disease is a neurodegenerative disease characterised by the loss of recent memory and intellectual functions. We have devised a genetic circuit for transfection into microglia, a novel chassis in which standard assembly has never been used, to boost their ability to break down senile plaques, which are associated with Alzheimer’s disease, as well as to support and protect endangered neurons from microglia-mediated neuroinflammation.
 +
<br><br>
 +
</p>
 +
</div>
</div>
</div>

Latest revision as of 03:56, 5 October 2013

IGEM: INTELLIGENTLY GENETICALLY ENGINEERED MICROGLIA

Synthetic Biology Fights Alzheimer's Disease

This year, the UCL iGEM team is taking a radical new step with synthetic biology. We intend to explore the potential application genetic engineering techniques on the brain, because it is the site of some of the most subtle, and many of the most devastating medical conditions. Alzheimer’s Disease is a neurodegenerative disease characterised by the loss of recent memory and intellectual functions. We have devised a genetic circuit for transfection into microglia, a novel chassis in which standard assembly has never been used, to boost their ability to break down senile plaques, which are associated with Alzheimer’s disease, as well as to support and protect endangered neurons from microglia-mediated neuroinflammation.

Retrieved from "http://2013.igem.org/Team:UCL"