|
|
| (One intermediate revision not shown) |
| Line 1: |
Line 1: |
| | {{:Team:Michigan_Template}} | | {{:Team:Michigan_Template}} |
| | + | <html> |
| | + | <div class="body"> |
| | + | <div id="basic"> |
| | | | |
| - | <!-- *** What falls between these lines is the Alert Box! You can remove it from your pages once you have read and understood the alert *** -->
| |
| | | | |
| - | <html>
| + | |
| - | <div id="box" style="width: 700px; margin-left: 137px; padding: 5px; border: 3px solid #000; background-color: #fe2b33;"> | + | <p> |
| - | <div id="template" style="text-align: center; font-weight: bold; font-size: large; color: #f6f6f6; padding: 5px;">
| + | |
| - | This is a template page. READ THESE INSTRUCTIONS.
| + | Recent studies have just started to explore the possibility of utilizing existing recombination systems that flip segments of DNA to store information and perform computations. However, the only systems studied so far are not completely unidirectonal in their ability to flip a segment of DNA. Other systems studied to date have consisted of one unidirectional recombinase capable of flipping a segment of DNA in only one direction, but have lacked a complementary unidrectional recombinase to flip the DNA back in only the opposite direction. Instead, previous systems have relied on “recombination directionality factors” which when complexed with the unidirectional recombinase, reverse the direction in which it flips the DNA segment. The fim system from E. coli has been shown to contain 2 unidirectional recombinases, hbif and fime, which flip a promoter-containing segment of DNA. Our project seeks to engineer the fim switch by replacing the native promoter with another promoter. We plan to demonstrate that it can function as a reliable and efficient biological transistor, or “transcriptor”. Beyond storing information and performing basic computations, the system would serve as a very useful, tightly controlled switch. |
| - | </div>
| + | </p> |
| - | <div id="instructions" style="text-align: center; font-weight: normal; font-size: small; color: #f6f6f6; padding: 5px;">
| + | |
| - | You are provided with this team page template with which to start the iGEM season. You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki. You can find some examples <a href="https://2009.igem.org/Help:Template/Examples">HERE</a>.
| + | |
| - | </div> | + | |
| - | <div id="warning" style="text-align: center; font-weight: bold; font-size: small; color: #f6f6f6; padding: 5px;">
| + | |
| - | You <strong>MUST</strong> have all of the pages listed in the menu below with the names specified. PLEASE keep all of your pages within your teams namespace.
| + | |
| | </div> | | </div> |
| | </div> | | </div> |
| | </html> | | </html> |
| - |
| |
| - | <!-- *** End of the alert box *** -->
| |
| - |
| |
| - |
| |
| - |
| |
| - | {|align="justify"
| |
| - | |You can write a background of your team here. Give us a background of your team, the members, etc. Or tell us more about something of your choosing.
| |
| - | |[[Image:Michigan_logo.png|200px|right|frame]]
| |
| - | |-
| |
| - | |
| |
| - | ''Tell us more about your project. Give us background. Use this as the abstract of your project. Be descriptive but concise (1-2 paragraphs)''
| |
| - | |[[Image:Michigan_team.png|right|frame|Your team picture]]
| |
| - |
| |
| - |
| |
| - | Recent studies have just started to explore the possibility of utilizing existing recombination systems that flip segments of DNA, to store information and perform computations. However, the only systems studied so far are not completely unidirectonal in their ability to flip a segment of DNA. Other systems studied to date have consisted of one unidirectional recombinase capable of flipping a segment of DNA in only one direction, but have lacked a complementary unidrectional recombinase to flip the DNA back in only the opposite direction. Instead, previous systems have relied on “recombination directionality factors”, which when complexed with the unidirectional recombinase, reverse the direction in which it flips the DNA segment. The fim system from E. coli, has been shown to contain 2 unidirectional recombinases, hbif and fime, which flip a promoter containing segment of DNA. Our project seeks to engineer the fim switch by replacing the native promoter with another promoter. We plan to demonstrate that it can function as a reliable and efficient biological transistor, or “transcriptor”. Beyond storing information and performing basic computations, the system would serve as a very useful, tightly controlled switch.
| |
| - | |-
| |
| - | |
| |
| - | |align="center"|[[Team:Michigan | Team Michigan]]
| |
| - | |}
| |
| - |
| |
| - | <!--- The Mission, Experiments --->
| |
| - |
| |
| - | {| style="color:#1b2c8a;background-color:#0c6;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="62%" align="center"
| |
| - | !align="center"|[[Team:Michigan|Home]]
| |
| - | !align="center"|[[Team:Michigan/Team|Team]]
| |
| - | !align="center"|[https://igem.org/Team.cgi?year=2013&team_name=Michigan Official Team Profile]
| |
| - | !align="center"|[[Team:Michigan/Project|Project]]
| |
| - | !align="center"|[[Team:Michigan/Parts|Parts Submitted to the Registry]]
| |
| - | !align="center"|[[Team:Michigan/Modeling|Modeling]]
| |
| - | !align="center"|[[Team:Michigan/Notebook|Notebook]]
| |
| - | !align="center"|[[Team:Michigan/Safety|Safety]]
| |
| - | !align="center"|[[Team:Michigan/Attributions|Attributions]]
| |
| - | |}
| |
Recent studies have just started to explore the possibility of utilizing existing recombination systems that flip segments of DNA to store information and perform computations. However, the only systems studied so far are not completely unidirectonal in their ability to flip a segment of DNA. Other systems studied to date have consisted of one unidirectional recombinase capable of flipping a segment of DNA in only one direction, but have lacked a complementary unidrectional recombinase to flip the DNA back in only the opposite direction. Instead, previous systems have relied on “recombination directionality factors” which when complexed with the unidirectional recombinase, reverse the direction in which it flips the DNA segment. The fim system from E. coli has been shown to contain 2 unidirectional recombinases, hbif and fime, which flip a promoter-containing segment of DNA. Our project seeks to engineer the fim switch by replacing the native promoter with another promoter. We plan to demonstrate that it can function as a reliable and efficient biological transistor, or “transcriptor”. Beyond storing information and performing basic computations, the system would serve as a very useful, tightly controlled switch.
"
