Team:Bonn

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        <img src="https://static.igem.org/mediawiki/2013/1/1f/Bonn_Logo_Batch.png" height="250px" style="float:left; display:inline;">
 
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        <div style="padding-top:50px;margin-left:230px;width:700px;">
 
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          Regulating protein activity is important throughout lifescience research. Even though there are several
 
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          systems available for regulation of proteins all suffer from certain disadvantages. </br>
 
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          <span style="font-style:italic">Aiming to overcome all of these drawbacks we engineer a novel system for
 
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          light dependend regulation of protein degradation resulting in a rapid change of protein activity.
 
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          Our system can be not only of great importance for fundamental science to investigate protein function but
 
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          also for accurate control of bioreactors and biological machines.</span> </div>
 
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            Project
 
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            Making versatile control of biological machines easily possible for everybody we engineer a system for
 
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            light dependend control of protein activity per protein degradation.</br>
 
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            Harnessing the ClpXP protease system of prokaryotes enables degradation of a peptid tag (ssrA) fused 
 
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            protein upon induction with the adaptor protein SspB. Using a Split version of SspB, protein degradation is
 
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            activated through heterodimerisation of both SspB parts.We utilize light dependent heterodimerisation to eventually obtain light inducible degradation. </br>
 
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            Modelling of the light dependency of protein degradation will even make simple and accurate control of
 
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            protein activity for any desired level of activity possible.</br>
 
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            As a proof of principle we investigate degradation of the fluorescent reporter protein mCherry.</br>
 
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            Find out more about </br>
 
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              split SspB </br>
 
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              light inducible heterodimerisation </br>
 
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              our protocols </br>
 
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          Background
 
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            To enable protein degradation we decided on one proteases system (ClpXP), which allows specific degradation
 
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            of proteins, is highly conserved and well established.
 
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            For light dependency we compared several systems to finally find the best suited one. We created a
 
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            comprehensive overview of all systems making artificially light control possible so that everyone can
 
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            easily choose the optimal system for his approach.
 
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            Find out more about </br>
 
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              the ClpXP protease System </br>
 
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              our Comparison of several light sensitive systems</br>
 
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            Human Practice
 
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            Team
 
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Latest revision as of 13:00, 27 October 2013

Retrieved from "http://2013.igem.org/Team:Bonn"