Team:USTC CHINA/Project/Background
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<p align="justify">In our world, billions of people are suffering from contagions while only parts of contagions can be effectively prevented by existing vaccines. The disadvantages of traditional vaccines, like being produced and purified with strict requirements on temperature, have limited their application, especially in developing countries.<p> | <p align="justify">In our world, billions of people are suffering from contagions while only parts of contagions can be effectively prevented by existing vaccines. The disadvantages of traditional vaccines, like being produced and purified with strict requirements on temperature, have limited their application, especially in developing countries.<p> | ||
<h3>The Comparison of Different Vaccine Delivery Ways<h3> | <h3>The Comparison of Different Vaccine Delivery Ways<h3> | ||
- | <img src="https://static.igem.org/mediawiki/2013/d/d7/USTC_CHINA_Traditional_needles.png" width="600" height="375" /><p align="justify">One solution to the problems is making change in drug delivery and create an in situ expression system based on synthetic biology.This year, we designed a new biological transdermal vaccine patch called T- | + | <img src="https://static.igem.org/mediawiki/2013/d/d7/USTC_CHINA_Traditional_needles.png" width="600" height="375" /><p align="justify">One solution to the problems is making change in drug delivery and create an in situ expression system based on synthetic biology.This year, we designed a new biological transdermal vaccine patch called T-vaccine.<p> |
<img src="https://static.igem.org/mediawiki/2013/3/31/USTC_CHINA_advantages_T-vaccine.png" width="600" height="600" /> | <img src="https://static.igem.org/mediawiki/2013/3/31/USTC_CHINA_advantages_T-vaccine.png" width="600" height="600" /> | ||
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<p align="justify">When this idea first stroke us, it seemed that our dream is too naive and unpractical. | <p align="justify">When this idea first stroke us, it seemed that our dream is too naive and unpractical. | ||
The most obvious problem is to make antigen get across the skin barrier, and we looked up various transdermal methods, like Iontophoresis, Sonophoresis, Microneedles,all of which require special equipment and can harm skin. Our idea remained unrealistic until we find Transdermal peptide 1.<p> | The most obvious problem is to make antigen get across the skin barrier, and we looked up various transdermal methods, like Iontophoresis, Sonophoresis, Microneedles,all of which require special equipment and can harm skin. Our idea remained unrealistic until we find Transdermal peptide 1.<p> | ||
- | <p align="justify"> | + | <p align="justify">TD1 is an eleven amino acid peptide, which can greatly facilitate macromolecule transdermal delivery through intact skin. This was first discovered by professor Wen Longping in our university and the results were published on Nature biotechnology.<p> |
TD1 Sequence<br> | TD1 Sequence<br> | ||
<img src="https://static.igem.org/mediawiki/2013/9/97/%E9%80%8F%E7%9A%AE%E8%82%BD%E5%BA%8F%E5%88%97.png" width="580" height="50" /> | <img src="https://static.igem.org/mediawiki/2013/9/97/%E9%80%8F%E7%9A%AE%E8%82%BD%E5%BA%8F%E5%88%97.png" width="580" height="50" /> |
Latest revision as of 03:40, 29 October 2013