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Team:Toronto
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| - | <!-- *** What falls between these lines is the Alert Box! You can remove it from your pages once you have read and understood the alert *** | + | {| style="color:#AADD99;background-color:#AA00EE;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="62%" align="center" |
| + | !align="center"|[[Team:Toronto|Home]] | ||
| + | !align="center"|[[Team:Toronto/Team|Team]] | ||
| + | !align="center"|[https://igem.org/Team.cgi?year=2013&team_name=Toronto Official Team Profile] | ||
| + | !align="center"|[[Team:Toronto/Project|Project]] | ||
| + | !align="center"|[[Team:Toronto/Parts|Parts Submitted to the Registry]] | ||
| + | !align="center"|[[Team:Toronto/Modeling|Modeling]] | ||
| + | !align="center"|[[Team:Toronto/Notebook|Notebook]] | ||
| + | !align="center"|[[Team:Toronto/Safety|Safety]] | ||
| + | !align="center"|[[Team:Toronto/Attributions|Attributions]] | ||
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| + | <!-- *** What falls between these lines is the Alert Box! You can remove it from your pages once you have read and understood the alert *** | ||
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| + | ==Project Description== | ||
| + | Microorganisms frequently adopt a lifestyle in which they produce biofilm; excreting extracellular biopolymers allows them to accumulate and adhere to surfaces. Biofilms provide microbes with nutrients and protection for greater survival under conditions of environmental stress. We are researching the pathways that induce biofilm formation and maturation in ''E. coli'', with the goal of modulating surface-specific adhesion of ''E. coli'' biofilms. To this end, we are constructing and characterising ''E. coli'' strains, which contain targeted deletions or overexpress recombinant proteins that are critically involved in biofilm pathways – including the production of adhesion proteins and excretion of matrix polysaccharides. In response to environmental stimuli such as temperature, blue light, and sodium, the phenotype of each mutant ''E. coli'' strain will be quantified. The control of biofilm formation will have applications for engineering surface-specific adhesion in bioremediation, which we are pursuing in a related project on heavy metal precipitation. <span style="font-size: 150%;">In a larger context</span>, we are establishing the use of BioBricks to manipulate an entire, complex biological system. | ||
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|[[Image:Toronto_logo.png|200px|right|frame]] | |[[Image:Toronto_logo.png|200px|right|frame]] | ||
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|[[Image:Toronto_team.png|right|frame|Your team picture]] | |[[Image:Toronto_team.png|right|frame|Your team picture]] | ||
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Revision as of 14:39, 9 August 2013
| Home | Team | Official Team Profile | Project | Parts Submitted to the Registry | Modeling | Notebook | Safety | Attributions |
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Project Description
Microorganisms frequently adopt a lifestyle in which they produce biofilm; excreting extracellular biopolymers allows them to accumulate and adhere to surfaces. Biofilms provide microbes with nutrients and protection for greater survival under conditions of environmental stress. We are researching the pathways that induce biofilm formation and maturation in E. coli, with the goal of modulating surface-specific adhesion of E. coli biofilms. To this end, we are constructing and characterising E. coli strains, which contain targeted deletions or overexpress recombinant proteins that are critically involved in biofilm pathways – including the production of adhesion proteins and excretion of matrix polysaccharides. In response to environmental stimuli such as temperature, blue light, and sodium, the phenotype of each mutant E. coli strain will be quantified. The control of biofilm formation will have applications for engineering surface-specific adhesion in bioremediation, which we are pursuing in a related project on heavy metal precipitation. In a larger context, we are establishing the use of BioBricks to manipulate an entire, complex biological system.
