Team:Stanford-Brown

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<span id="abs-title" style="margin-top:-30px;"><a href="/Team:Stanford-Brown/Team/Apply">JOIN US IN 2014! CLICK HERE!</a></span>
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            <span id="abs-title" style="margin-top:-30px;"><a href="/Team:Stanford-Brown/AboutUs/Recruiting">COME JOIN US IN 2013! CLICK HERE!</a></span>
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             <span id="abs-title">ABSTRACT</span>
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                Astrobiology revolves around three central questions: "Where do we come from?", "Where are we going?", and "Are we alone?"  The Stanford-Brown iGEM team explored synthetic biology's untapped potential to address these questions. To approach the second question, the Hell Cell subgroup developed BioBricks that allow a cell to survive harsh extraterrestrial conditions. Such a toolset could create a space-ready synthetic organism to perform useful functions off-world. For example, the Biomining branch attempted to engineer bacteria to recycle used electronics by degenerating silica and extracting metal ions <i>in situ</i>. The Venus Life subproject grappled with the third key astrobiological question by exploring Carl Sagan's theory that life could exist in Venusian clouds. To this end, Venus Life designed a cell-cycle reporter to test for growth in aerosol within an adapted Millikan apparatus. Through this triad of projects, Stanford-Brown iGEM aims to illuminate synthetic biology's value as a tool for astrobiology.
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Communication is an integral part of life as we know it. This summer, we pursued four synthetic biology projects with the goal of improving communication across different mediums. On the atomic level, our <b>BioWires</B> project has created silver-incorporating DNA strands to use as nanowires, which could improve the cost and effectiveness of electronics. Our <b>CRISPR</B> project worked on a system for  passing DNA regulatory messages between cells, in effect creating transmissible vaccines. We also extrapolated proteins from the past to better understand early life on Earth for our <B>De-Extinction</B> project. Finally, we built a sucrose biosensor in <I>B. subtilis</I> that will be launched on the <b>EuCROPIS</B> satellite  into low-Earth orbit. <br><br>
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<big><B>We are the Stanford-Brown iGEM team, and we're connecting life on Earth to help us prepare for life beyond it.</B></big>
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             <div style="margin-top:15px; text-align:center; font-weight: 600; font-size: 18px;">ACCOMPLISHMENTS</div>
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             <div style="margin-top:15px; text-align:center; font-weight: 600; font-size: 18px;">ACHIEVEMENTS</div>
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                 <li> <a href="#"> Introduced Synthetic Biology as a tool for Astrobiology </a></li>
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                 <li> <a href="#">Top 16 at iGEM World Competition </a></li>
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                 <li> <a href="/Team:Stanford-Brown/Projects/BioWires">Demonstrated silver-ion incorporation in the DNA double-helix </a></li>
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                 <li> <a href="#">Best Natural BioBrick at Americas West Regionals </a></li>
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                 <li> <a href="/Team:Stanford-Brown/Projects/EuCROPIS">Worked with NASA and the German Space agency to develop BioBrick constructs for the EuCROPIS Satellite Mission</a></li>
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                 <li> <a href="/Team:Stanford-Brown/HellCell/Introduction">Isolated parts that improve resistance to extreme conditions in <i>Escherichia coli</i></a></li>
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                 <li> <a href="/Team:Stanford-Brown/Projects/CRISPR">Isolated and bricked components of two CRISPR-Cas systems</a></li>
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                <li> <a href="/Team:Stanford-Brown/VenusLife/Biosensing">Developed two cell-cycle dependent promoters for use as remote biosensors </a></li>
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                 <li> <a href="/Team:Stanford-Brown/Projects/De-Extinction">Designed and modeled ancestral proteins to understand early conditions of earth</a></li>
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                 <li> <a href="/Team:Stanford-Brown/Biomining/Harvesting">Improved part BBa_K133038 by standardizing ligation into flagella and engineered the <i>E. coli</i> flagellum to extract metals <i>in situ</i></a></li>
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<li> <a href="/Team:Stanford-Brown/Projects/De-Extinction#Evolutionary_Modeling">Collaborated with Dr. Rich Lenski to use 25 years of evolutionary data to model and text bioinformatics software </li>
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                <li> <a href="/Team:Stanford-Brown/VenusLife/Modeling">Modeled bacterial growth in the Venusian atmosphere </a></li>
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                 <li> <a href="/Team:Stanford-Brown/Projects/HumanPractices">Authored reports on the the ethics of de-extinction and the iGEM workflow </a></li>
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                <li> <a href="/Team:Stanford-Brown/HumanPractices/Introduction">Wrote Guides to Bioethics and Gene Patent Law </a></li>
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                <li> <a href="https://2013.igem.org/Team:UC_Davis/Database/Initial_Population">Collaborated with team UC Davis to characterize promoter strengths</a></li>
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                <li> <a href="http://www.wired.com/wiredscience/2012/08/engineering-bacteria-for-mars/">Featured in Wired Magazine and Cal Academy of Sciences </a></li>
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<li> <a href="https://2013.igem.org/Edinburgh_University">Consulted with Team Edinburgh on <i>B. subtilis</i> methods and protocols </li>
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                <li> <a href="http://www.facebook.com/IgemMemes">Created and maintained iGEM memes </a></li>
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<li> <a href="https://2013.igem.org/Team:Stanford-Brown/Team/Outreach#Teaching_a_BioEngineering_Bootcamp">Instructed high school seniors in the basics of synthetic biology and how to build an iGEM team </li>
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<li> <a href="https://2013.igem.org/Team:Stanford-Brown/Team/Outreach#Bay_Area_and_NYC_Maker_Faires">Demonstrated SynBio and iGEM to the public at Maker Faire in SF and NYC </li>
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<li> <a href="http://www.facebook.com/IgemMemes">Curated iGEM memes with additional social outreach via Instagram and Twitter </li>
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<li> <a href="https://2013.igem.org/Team:Stanford-Brown/Team/Outreach#Podcasts_and_Memes">Produced iGEM podcast to discuss SynBio topics </li>
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             <p class="brief">Atomic Communication
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          <div class="feature"><a href="https://2012.igem.org/Team:Stanford-Brown/HellCell/Introduction"><img src="https://static.igem.org/mediawiki/2012/5/5a/HellCell.png" width="281"/></a>
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             <p class="brief">Surviving in the harsh conditions of space is not easy for an organism.  Extreme temperatures, desiccation, and pressures are only some of the problems an intrepid bacterium might face on its journey.  We successfully strengthened our organisms with some of these abilities––desiccation and extreme basicity--in preparation for a journey into space!
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           <div class="feature"><a href="https://2012.igem.org/Team:Stanford-Brown/VenusLife/Introduction"><img src="https://static.igem.org/mediawiki/2012/d/dc/Venus.png" width="281"/></a>
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             <p class="brief">Cellular Communication
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             <p class="brief">The surface of Venus is a harsh and unforgiving environment.  However, research suggests that there may be layers of its atmosphere that are more temperate.  To prepare for tests to see if organisms can survive in the clouds of Venus, we successfully developed cell-cycle dependent reporters to tell us when our cells are happy and dividing!
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           <div class="feature"><a href="https://2012.igem.org/Team:Stanford-Brown/Biomining/Introduction"><img src="https://static.igem.org/mediawiki/2012/6/60/Biomining.png" width="281" /></a>
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            <p class="brief">Temporal Communication
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             <p class="brief">If we are to colonize space, we are going to need rare metals for materials. But bringing heavy duty equipment for traditional mining is not very viable at all! Bacteria and other biological organisms can be used to extract rare metals from sediment. Bacteria could mine asteroids and do all the work for us, and we equipped their flagella with the tools to do so!
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             <p class="brief">Spatial Communication
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Latest revision as of 04:12, 16 November 2013

JOIN US IN 2014! CLICK HERE!
ABSTRACT

Communication is an integral part of life as we know it. This summer, we pursued four synthetic biology projects with the goal of improving communication across different mediums. On the atomic level, our BioWires project has created silver-incorporating DNA strands to use as nanowires, which could improve the cost and effectiveness of electronics. Our CRISPR project worked on a system for passing DNA regulatory messages between cells, in effect creating transmissible vaccines. We also extrapolated proteins from the past to better understand early life on Earth for our De-Extinction project. Finally, we built a sucrose biosensor in B. subtilis that will be launched on the EuCROPIS satellite into low-Earth orbit.

We are the Stanford-Brown iGEM team, and we're connecting life on Earth to help us prepare for life beyond it.

ACHIEVEMENTS

Atomic Communication

Cellular Communication

Temporal Communication

Spatial Communication

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