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Team:HZAU-China/Home
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| - | <p style="font-family:times new roman;">Our idea comes from Yersinia pestis and fleas. We make use of fleas as our moving injector. When fleas feed on blood from dogs, our vaccine vector Bacillus subtilis will be regurgitated into blood and successfully transferred to mammalian host. Bacillus subtilis can express antigens which can stimulate the immunity of dogs. Meanwhile, endogenous or exogenous expression of "Antimicrobial Peptides" by B. subtilis can kill Yersinia pestis in fleas. In this way we achieved a safe moving vaccine factory.</p> | + | <p style="font-family:times new roman;">Our idea comes from <i>Yersinia pestis</i> and fleas. We make use of fleas as our moving injector. When fleas feed on blood from dogs, our vaccine vector <i>Bacillus subtilis</i> will be regurgitated into blood and successfully transferred to mammalian host. <i>Bacillus subtilis</i> can express antigens which can stimulate the immunity of dogs. Meanwhile, endogenous or exogenous expression of "Antimicrobial Peptides" by <i>B. subtilis</i> can kill <i>Yersinia pestis</i> in fleas. In this way we achieved a safe moving vaccine factory.</p> |
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| - | <p style="font-family:Arial,Helvetica,sans-serif;font-size:30px;font-color:#fff;text-align:center; padding-left:8px;padding-right:8px;padding-top:1px;margin:0px;"><a href="https://2013.igem.org/Team:HZAU-China/Project/Flea_and_Yersinia_pestis">Yersinia pestis and flea</a></p> | + | <p style="font-family:Arial,Helvetica,sans-serif;font-size:30px;font-color:#fff;text-align:center; padding-left:8px;padding-right:8px;padding-top:1px;margin:0px;"><a href="https://2013.igem.org/Team:HZAU-China/Project/Flea_and_Yersinia_pestis"><i>Yersinia pestis</i> and flea</a></p> |
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| - | <p style="font-family:Arial,Helvetica,sans-serif;font-size:17px;font-color:#000;text-align:justify;padding:10px; margin:0px;">Yersinia pestis can form biofilms to colonize the proventricular of flea. Blocked fleas can transfer Yersinia pestis to host. The mechanism has been widely researched. Although it is too early for us to release clean fleas, we do spend a lot of time in thinking of this mechanism. You can find the details of this interesting mechanism in this section.</p> | + | <p style="font-family:Arial,Helvetica,sans-serif;font-size:17px;font-color:#000;text-align:justify;padding:10px; margin:0px;"><i>Yersinia pestis</i> can form biofilms to colonize the proventricular of flea. Blocked fleas can transfer <i>Yersinia pestis</i> to host. The mechanism has been widely researched. Although it is too early for us to release clean fleas, we do spend a lot of time in thinking of this mechanism. You can find the details of this interesting mechanism in this section.</p> |
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Latest revision as of 11:21, 9 November 2013
PROJECT: Safe Moving Vaccine Factory
ABSTRACT
Our idea comes from Yersinia pestis and fleas. We make use of fleas as our moving injector. When fleas feed on blood from dogs, our vaccine vector Bacillus subtilis will be regurgitated into blood and successfully transferred to mammalian host. Bacillus subtilis can express antigens which can stimulate the immunity of dogs. Meanwhile, endogenous or exogenous expression of "Antimicrobial Peptides" by B. subtilis can kill Yersinia pestis in fleas. In this way we achieved a safe moving vaccine factory.
