Team:Penn

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<br><center><a href = 'https://docs.google.com/forms/d/188iefj_j6gBvrHC0IS3rG2zBelaVuy-JddYNN7QF8_Y/viewform'>Interested in joining the team? Submit your application for Penn iGEM 2014 here. </a></center>
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<TR><TD ALIGN="center"><a href='https://2013.igem.org/Team:Penn/MaGellinToolbox'><IMG SRC="http://farm6.staticflickr.com/5523/10529365546_355d2fe7fc.jpg" width="240" height="auto"></a></TD></TR>
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</TABLE><br><a href='https://2013.igem.org/Team:Penn/MaGellinToolbox'>Constructed a toolbox for developing site-specific DNA methylases</a></TD>
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<TD ALIGN = "center" width='240'> <TABLE
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<TR><TD ALIGN="center"><a href='https://2013.igem.org/Team:Penn/AssayOverview'><IMG SRC="http://farm3.staticflickr.com/2836/10529350575_dfb38e3538.jpg" width="240" height="auto"></a></TD></TR>
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</TABLE><br><a href='https://2013.igem.org/Team:Penn/AssayOverview'>Created a standardized assay for site-specific methylases</a></TD>
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<TR><TD ALIGN="center"><a href='https://2013.igem.org/Team:Penn/Software'><IMG SRC="http://farm4.staticflickr.com/3742/10529401844_cc5f713a48.jpg" width="240" height="auto"></a></TD></TR>
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</TABLE><br><a href='https://2013.igem.org/Team:Penn/Software'>Developed software to automate analysis of our assay</a></TD>
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<h2>Accomplishments:</h2>
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Our goal was to enable epigenetic engineering. We believe synthetic biological systems should be as subtle and robust as their naturally occurring counterparts. Moreover, we wanted to begin development on much-needed second-generation epigenetic therapeutics.</b><br/>
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<TR><TD ALIGN="center"><a href='https://2013.igem.org/Team:Penn/MethylaseOverview'><IMG SRC="http://farm6.staticflickr.com/5478/10529350195_2c54c496e5.jpg" width="240" height="auto"></a></TD></TR>
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</TABLE><br><a href='https://2013.igem.org/Team:Penn/MethylaseOverview'>Designed and characterized a novel TALE-methylase fusion protein</a> <br></TD>
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<li><a href="https://2013.igem.org/Team:Penn/FusionMotivation">Designed a functional fusion protein to facilitate epigenetic engineering, with numerous advantages over existing technologies</a></li>
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<li><a href="https://2013.igem.org/Team:Penn/MaGellinMotivation">Validated a novel methylation assay, MaGellin, to accelerate development of epigenetic engineering tools</a></li>
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<TR><TD ALIGN="center"><a href='https://2013.igem.org/Team:Penn/hpoverview'><IMG SRC="http://farm4.staticflickr.com/3670/10529586493_833c6216ee.jpg" width="240" height="auto"></a></TD></TR>
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<li><a href="https://2013.igem.org/Team:Penn/MaGellinSoftware">Built a complementary MaGellin software package to automate experimental analysis</a></li>
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</TABLE><br><a href='https://2013.igem.org/Team:Penn/hpoverview'>Introduced synthetic biology to the community</a></TD>
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<li><a href="https://dl.dropboxusercontent.com/u/11828463/MaGellin%20Spec%20Sheet.pdf">Created a specification sheet for the MaGellin Assay workflow, to facilitate quick epigenetic assay studies.</a></li>
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<li><a href="https://2013.igem.org/Team:Penn/Biobricks">BioBrick'ed our MaGellin plasmid so other iGEM teams can build off our work</a></li>
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<li><a href="https://2013.igem.org/Team:Penn/Too_Soon_To_Treat">Wrote an article on the ethical implications of epigenetic interventions, accepted for publication in the "nation's premier peer-reviewed undergraduate bioethics journal" </a></li>
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<li><a href="https://2013.igem.org/Team:Penn/LIMS">Developed an open-source Laboratory Information Management System to help teams keep their labs organized </a></li>
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<li><a href="https://2013.igem.org/Team:Penn/Outreach">Promoted iGEM, synthetic biology, and our research at numerous outreach events to inspire future scientists</a></li>
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<li><a href="http://mackinstitute.wharton.upenn.edu/2013/its-not-all-in-the-dna-penn-team-benefits-from-mack-institute-sponsorship-in-synthetic-biology-competition/">Featured in an interview</a></li>
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<li><a href="https://2013.igem.org/Jamborees">North American regional winners and winners of Best BioBrick Measurement Approach award for our gel-electrophoresis assay.</a></li>
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<TR><TD ALIGN="center"><a href='https://2013.igem.org/Team:Penn/Too_Soon_To_Treat'><IMG SRC="http://farm4.staticflickr.com/3815/10529365086_82d164e2b1.jpg" width="240" height="auto"></a></TD></TR>
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</TABLE><br><a href='https://2013.igem.org/Team:Penn/Too_Soon_To_Treat'>Published an article on the ethics of epigenetic engineering</a></TD>
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<TR><TD ALIGN="center"><a href='https://2013.igem.org/Team:Penn/Team'><IMG SRC="http://farm6.staticflickr.com/5533/10529401504_677c4f296a.jpg" width="240" height="auto"></a></TD></TR>
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</TABLE><br><a href='https://2013.igem.org/Team:Penn/Team'>Our team</a> <br> <br> <br></TD>
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<TR><TD ALIGN="center"><a href='https://2013.igem.org/Team:Penn/Achievements'><IMG SRC="http://farm4.staticflickr.com/3739/10529350025_2db22731e9.jpg" width="240" height="auto"></a></TD></TR>
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</TABLE><br><a href='https://2013.igem.org/Team:Penn/Achievements'>Grand Prize Winner, North America<br>Best Experimental Measurement Approach, North America</a></TD>
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<TR><TD ALIGN="center"><a href='http://articles.philly.com/2013-11-27/news/44490110_1_synthetic-biology-research-project-international-genetically-engineered-machine'><IMG SRC="http://farm8.staticflickr.com/7397/10529350205_c12e2cd367.jpg" width="240" height="auto"></a></TD></TR>
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</TABLE><br><a href='http://articles.philly.com/2013-11-27/news/44490110_1_synthetic-biology-research-project-international-genetically-engineered-machine'>Featured in a Philadelphia Inquirer article</a> <br> <br> <br></TD>
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<center><a href = "https://2013.igem.org/Team:Penn"> Home  </a> <a href = "https://static.igem.org/mediawiki/2013/e/e5/Spec_Sheet.pdf" >Spec Sheet</a> <a href = "https://2013.igem.org/Team:Penn/sitemap" >Sitemap</a>
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Latest revision as of 16:42, 15 January 2014

Penn iGEM



Interested in joining the team? Submit your application for Penn iGEM 2014 here.



Constructed a toolbox for developing site-specific DNA methylases

Created a standardized assay for site-specific methylases

Developed software to automate analysis of our assay

Designed and characterized a novel TALE-methylase fusion protein

Introduced synthetic biology to the community

Published an article on the ethics of epigenetic engineering

Our team



Grand Prize Winner, North America
Best Experimental Measurement Approach, North America

Featured in a Philadelphia Inquirer article


Retrieved from "http://2013.igem.org/Team:Penn"