Team:Virginia

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!align="center"|[[Team:Virginia|Home]]
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!align="center"|[[Team:Virginia/Team|Team]]
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<title>VGEM Welcomes You!</title>
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!align="center"|[https://igem.org/Team.cgi?year=2013&team_name=Virginia Official Team Profile]
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!align="center"|[[Team:Virginia/Project|Project]]
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!align="center"|[[Team:Virginia/Human_Practices|Human Practices]]
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!align="center"|[[Team:Virginia/Parts|Parts Submitted to the Registry]]
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!align="center"|[[Team:Virginia/Modeling|Modeling]]
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!align="center"|[[Team:Virginia/Safety|Safety]]
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<h3>Preliminary Description:</h3>
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<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Safety remains a serious issue in synthetic biology; in particular, the development of drug delivery via targeted, live bacteria presents significant concern. Minicells provide a safe alternative to live bacteria while still retaining many of the features that make the latter such a promising potential chassis.
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<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Minicells result from aberrant cell division leaving one of the daughter cells significantly smaller (typically ~400 nm) and without chromosomal DNA; consequently, minicells are unable to replicate or cause infection. As then maintain the parent cell’s physical characteristics, including proton gradients, surface proteins, and plasmid DNA, minicells serve as an ideal chassis for receptor-targeted drug delivery.
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<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;We plan to create a standardized BioBrick for the creation of E. coli minicells through IPTG induction of FtsZ, a gene which causes aberrant cell division when overexpressed. Our modeling efforts focus on identifying the most efficient level of such IPTG induction.
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<p>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Although minicells fail to cause infection because of their inability to replicate, recognition of the LPS and surface proteins by the human immune system may lead to septic shock. To prevent any such possibility, a weakened bacteria strain, IpxM, expressing Ail protein and polysialic acid will be used. Expressed on the cell surface, Ail avoids deposition in human serum while polysialic acid prevents activation of the complement system. By coupling these precautions with their inherent safety, minicells provide a safe, targeted chassis which may be employed in future synthetic biology research.
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</head>
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<body>
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<p id="VGEM"><a href="https://2013.igem.org/Team:Virginia"><span>V</span>GEM</a></p>
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<p><a href="http://www.virginia.edu/"> University of Virginia</a></p>
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</div>
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  <div id="menu11">
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    <ul>
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        <li>
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                <span class="title">Home</span>
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                <span class="text"><a href="https://2013.igem.org/Team:Virginia">The start</a></span>
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        </li>
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        <li>
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        <span class="title">Project</span>
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                <span class="text">
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                <p><a href="https://2013.igem.org/Team:Virginia/Project_Overview">Overview</a></p>
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                <p><a href="https://2013.igem.org/Team:Virginia/Background">Background</a></p>
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                <p><a href="https://2013.igem.org/Team:Virginia/Parts">Parts</a></p>
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                <p><a href="https://2013.igem.org/Team:Virginia/Results">Results</a></p>
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                <p><a href="https://2013.igem.org/Team:Virginia/Modeling">Modeling</a></p>
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                <p><a href="https://2013.igem.org/Team:Virginia/Software">Software</a></p>
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</p>
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                <p><a href="https://2013.igem.org/Team:Virginia/Chassis_Improvements">Chassis Improvements</a></p></span>
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        </li>
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        <li>
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                <span class="title">Notebook</span>
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                <span class="text">
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                <p><a href="https://2013.igem.org/Team:Virginia/Notebook_Overview">Overview</a></p>
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                <p><a href="https://2013.igem.org/Team:Virginia/Notebook">Notebook</a></p>
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                <p><a href="https://2013.igem.org/Team:Virginia/Protocols">Protocols</a></p>
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                <p><a href="https://2013.igem.org/Team:Virginia/Gallery">Gallery</a></p></span>
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        </li>
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        <li>
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                          <span class="title">Human Practices</span>
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                <span class="text">
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                <p><a href="https://2013.igem.org/Team:Virginia/Human_Practices_Overview">Overview</a></p>
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                <p><a href="https://2013.igem.org/Team:Virginia/Safety Considerations">Safety Considerations</a></p>
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                <p><a href="https://2013.igem.org/Team:Virginia/High_School_Education_Series">High School Education Series</a></p>
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                <p><a href="https://2013.igem.org/Team:Virginia/Documentary">Documentary</a></p>
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                <p><a href="https://2013.igem.org/Team:Virginia/Media_Coverage">Media Coverage</a></p>
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</span>
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        </li>
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        <li>
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                <span class="title">Team</span>
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  <span class="text">
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                <p><a href="https://2013.igem.org/Team:Virginia/Team_Overview">Overview</a></p>
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                <p><a href="https://2013.igem.org/Team:Virginia/Bios">Bios</a></p>
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                <p><a href="https://igem.org/Team.cgi?year=2013&team_name=Virginia">Profile</a></p>
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                <p><a href="https://2013.igem.org/Team:Virginia/Sponsors">Sponsors</a></p>
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      <p><a href="https://2013.igem.org/Team:Virginia/Attributions">Attributions</a></p></span></li></ul></div></div>
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    <img id="image1" src="https://static.igem.org/mediawiki/2013/d/d3/New_banner.png" />
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    <img id="image3" src="https://static.igem.org/mediawiki/2013/2/2b/Screen_Shot_2013-09-27_at_11.10.07_PM.png" />
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    <img id="image4" src="https://static.igem.org/mediawiki/2013/e/e1/Screen_Shot_2013-09-27_at_11.32.44_PM.png" />
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    <div id="slider">
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    <a href="#image1">1</a>
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    <a href="#image2">2</a>
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    <a href="#image3">3</a>
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    <a href="#image4">4</a>
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    <a href="#image5">5</a>
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</div>
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<div class="fourfocus">
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  <div id="boxes"><div id="fbox1"><a href="https://2013.igem.org/Team:Virginia/Project_Overview"><img src="https://static.igem.org/mediawiki/2013/c/c2/Vgemplates.jpg" width="235" height="235" alt="" /></a>
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<h2>Project</h2>
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<p>Learn more about the exciting development of minicells as a safe and effective chassis.</p>
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  </div>
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  <div id="fbox2"><a href="https://2013.igem.org/Team:Virginia/Notebook"><img src="https://static.igem.org/mediawiki/2013/thumb/4/4e/Vgemopennotebook.jpg/800px-Vgemopennotebook.jpg" width="235" height="235" alt="" /></a>
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<h2>Notebook</h2>
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<p>See how we spent our summer of science.</p>
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  </div>
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<div id="fbox3"><a href="https://2013.igem.org/Team:Virginia/Human_Practices_Overview"><img src="https://static.igem.org/mediawiki/2013/8/86/VgemClass_7.jpg" width="235" height="235" alt="" /></a>
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<h2>Human Practices</h2>
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<p>Discover the local and global impact our iGEM team has made.</p>
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</div>
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<div id="fbox4"><a href="https://2013.igem.org/Team:Virginia/Team_Overview"><img src="https://static.igem.org/mediawiki/2013/thumb/5/59/VgemTeam_photo_2.jpg/546px-VgemTeam_photo_2.jpg" width="235" height="235" alt="" /></a>
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<h2>Team</h2>
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<p>Meet the brains and brawn behind the project.</p>
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</div></div>
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</div>
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<div class="bottom">
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<div id="featured-wrapper">
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<div id="sponsors">
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<div id="btitle"><p><b>Sponsors</b><br/>
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<span><font color="white">Funding the Science</font></span></p></div>
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<p><font color="white">Without our sponsors, this year's iGEM team would not be in existence. Thank you.</font></p>
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<ul class="style4">
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<li class="first"><a href="http://www.virginia.edu/vpr/biography.html"><font color="white">Tom Skalak, Vice President of Research at UVA</font></a></li>
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<li><a href="http://medicine.virginia.edu/"><font color="white">UVA Medical School</font></a></li>
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<li><a href="http://seas.virginia.edu/"><font color="white">UVA School of Engineering and Applied Science</font></a></li>
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                <li><a href="http://artsandsciences.virginia.edu/home/index.html"><font color="white">UVA College of Arts and Sciences</font></a></li>
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                <li><a href="#"><font color="white">Alumni Lacy Fund</font></a></li>
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</ul>
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<a href="https://2013.igem.org/Team:Virginia/Sponsors" class="button-style"><font color="#66ccff">Official Sponsors Page</font></a> </div>
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<div id="dates">
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<p id="btitle"><b>Competition Events</b><br/>
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<span><font color="white">Next Stop: MIT!</font></span></p>
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<ul class="style3">
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<li class="first">
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<p class="date">September<b>18</b></p>
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<h3>Biobrick Part Due</h3>
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<p><a href="http://parts.igem.org/Main_Page"><font color="white">All DNA due to the iGEM registry.</font></a></p>
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</li>
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<li>
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<p class="date">October<b>4-6</b></p>
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<h3>North America Regional Jamboree</h3>
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<p><a href="http://www.utoronto.com/"><font color="white">University of Toronto, Ontario, CA</font></a></p>
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</li>
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<li>
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<p class="date">November<b>1-4</b></p>
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<h3>World Championship Jamboree</h3>
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<p><a href="http://www.mit.edu/"><font color="white">MIT, Cambridge, USA</font></a></p>
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</li>
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<li>
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</ul>
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</div>
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<div id="updates">
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<p id="btitle"><b>Recent Updates</b><br />
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<span><font color="white">Team Progress</font></span></p>
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<ul class="style4">
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<li class="first"><font color="white">Advancing to Worlds!</font> <p><font color="white">Awarded Gold Medal & Best Human Practices Advance at Regionals</font></p></li>
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<li><a href="https://news.virginia.edu/content/uva-student-team-advances-global-genetic-engineering-championship"><font color="white">Featured in UVA Today!</font></a></li>
 +
<li><a href="http://wuvaonline.com/uva-students-win-genetics-competition/"><font color="white">Featured on WUVA!</font></a></li>
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<li><a href="http://www.nbc29.com/story/23733058/uva-genetic-engineering-team-developing-high-school-class?autoStart=true&topVideoCatNo=default&clipId=9431958"><font color="white">Featured on NBC 29!</font></a></li>
 +
<li><a href="http://www.dailyprogress.com/news/local/dna-workshop-at-renaissance-school/collection_9f7522e8-2242-11e3-a7a5-0019bb30f31a.html?mode=nogs"><font color="white">Featured in Daily Progress!</font></a></li>
 +
<li><a href="http://www.c-ville.com/bright-young-things-uvas-self-directed-synthetic-biology-stars/"><font color="white">Featured in CVille Weekly!</font></li>
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</ul>
 +
</div>
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</div>
 +
<div class="footer">
 +
<h3>&nbsp;</h3>
 +
<h3>Contact</h3>
 +
<p>Questions? Comments? Email us at <a href="virginia.igem@gmail.com">virginia.igem@gmail.com</a></p>
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</div>
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<!--- The Mission, Experiments --->
 

Latest revision as of 01:53, 29 October 2013

VGEM Welcomes You!

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Project

Learn more about the exciting development of minicells as a safe and effective chassis.

Notebook

See how we spent our summer of science.

Human Practices

Discover the local and global impact our iGEM team has made.

Team

Meet the brains and brawn behind the project.

 

Contact

Questions? Comments? Email us at virginia.igem@gmail.com

 

Retrieved from "http://2013.igem.org/Team:Virginia"