Team:Ciencias-UNAM

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Latest revision as of 04:20, 28 September 2013

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This year's project is an In vivo production of an antimicrobial peptide regulated by quorum sensing. We designed a synthetic system in E. coli to express an antimicrobial peptide (Cathelicidin LL-37) in vivo only in the presence of a quorum sensing molecule (AI-2) and expel it with an efflux pump in order to act against targeted gastrointestinal pathogens.

We are the team from Facultad de Ciencias, UNAM in Mexico City. Our team brings together students and teachers from all over the country, with various backgrounds and interests.

We submitted several devices mainly to test and use the following parts:
Cathelicidin LL-37: An antimicrobial peptide against bacterial infection.
MarA: A peptide responsible for an efflux pump in E. coli that is related to its resistance to cathelicidin and similar peptides.

The project we developed this year yielded several results. We achieved to characterise and contribute to the iGEM Registry. In this section we present what we think we are our best and main results.

Read the abstract

Meet the team

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-<div id="u54_rtf"><p style="text-align:left;"><span style="font-family:Arial;font-size:13px;font-weight:normal;font-style:normal;text-decoration:none;color:#666666;">Praesent libero arcu, convallis et dapibus sit amet, aliquet nec nibh. Nulla eu aliquam orci. Phasellus vitae nunc ut urna tincidunt accumsan vel ac dui. Donec tempus quis quam vitae ultrices. Vestibulum congue nec odio eget dictum. Sed tincidunt velit enim. Fusce metus augue, lobortis eget viverra sit amet, fringilla.</span></p></div>
+<div id="u54_rtf"><p align="justify"><span style="font-family:Arial;font-size:13px;font-weight:normal;font-style:normal;text-decoration:none;color:#666666;">This year's project is an <i>In vivo</i> production of an antimicrobial peptide regulated by <i>quorum sensing</i>. We designed a synthetic system in <i>E. coli</i> to express an antimicrobial peptide (Cathelicidin LL-37) <i>in vivo</i> only in the presence of a quorum sensing molecule (AI-2) and expel it with an efflux pump in order to act against targeted gastrointestinal pathogens.</span></p></div>
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+<div id="u55_rtf"><p align="justify"><span style="font-family:Arial;font-size:13px;font-weight:normal;font-style:normal;text-decoration:none;color:#666666;">We are the team from Facultad de Ciencias, UNAM in Mexico City. Our team brings together students and teachers from all over the country, with various backgrounds and interests.</span></p></div>
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+<div id="u56_rtf"><p align="justify"><span style="font-family:Arial;font-size:13px;font-weight:normal;font-style:normal;text-decoration:none;color:#666666;">We submitted several devices mainly to test and use the following parts:<br><b>Cathelicidin LL-37:</b> An antimicrobial peptide against bacterial infection.<br> <b>MarA:</b> A peptide responsible for an efflux pump in <i>E. coli</i> that is related to its resistance to cathelicidin and similar peptides.</span></p></div>
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+<div id="u57_rtf"><p align="justify"><span style="font-family:Arial;font-size:13px;font-weight:normal;font-style:normal;text-decoration:none;color:#666666;">The project we developed this year yielded several results. We achieved to characterise  and contribute to the iGEM Registry. In this section we present what we think we are our best and main results.</span></p></div>
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+<div id="u58_rtf"><p align="justify"><span style="font-family:Arial;font-size:13px;font-weight:bold;font-style:normal;text-decoration:none;color:#666666;">Read the abstract</span></p></div>
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+<div id="u59_rtf"><p align="justify;"><span style="font-family:Arial;font-size:13px;font-weight:bold;font-style:normal;text-decoration:none;color:#666666;">Meet the team</span></p></div>
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