Team:GeorgiaTech

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==Objective==  
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===planned results and significance of work===
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The objective for our project is ultimately to express human integrins on the surface of E.Coli cells.  By expressing
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human integrins on bacteria cells, we can manipulate the cells to respond to specific stimuli in their environment. The
 
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specific integrin we are trying to express on the E.Coli cell has the ability to bind to fibrinogen. If it is successfully placed
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on the cell, the cell will be able to bind to fibrinogen, effectively coagulating or clotting blood. This has applications in the
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medical field, where the integrin-containing E.Coli (BioBots, as we like to call them) can be administered as a topical solution
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and prevent excessive bleeding on major surface wounds.  A bacteria’s ability to express integrins has other applications as
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        <title>Georgia Tech iGEM</title>
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well. Since the bacteria will be able to send and receive signals to its environment, the bacteria can theoretically detect and
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locate cancer cells, as well as any other specific cell or structure of concern. These novel bacterial robots will represent the
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first prokaryotic use of heterodimeric integrins for a sensory function and will represent a platform that will enable future
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“design” of integrins sensory function through molecular evolution techniques.
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==Background==
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===problem statement, previous work, and/or description of need===
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Cells perform their intended functions not individually but collectively by forming temporally evolving, three dimensional structures
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comprised of clusters of cells, and through active or passive cell-cell and cell-extracellular matrix (ECM) interactions.
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Thus the development of engineered, integrative cellular systems that self-heal and adapt their microstructure to a variety of stimuli
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in the surrounding microenvironment will revolutionize the way bioengineers design. The goals of EBICS is to address the grand challenge
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of engineering multi-cellular biological machines that have desired functionalities and can perform prescribed tasks.
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These machines consist of sensing, information processing, actuation, protein expression, and transport elements that can be
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effectively combined to create functional units. Fortunately, nature provides plenty of inspiration through similarly functioning
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organisms and systems.  It is therefore feasible to assume that artificial materials and organisms of the future will incorporate such
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naturally inspired designs. The imitation of the aforementioned functions will require development of systems similar to specialized cells in the
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various human tissues.  The GT iGEM team will work toward the lofty goal of developing of cells and/or extracellular vesicles
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(e.g. platelets) that display designer sensory-response behaviors.  In particular, small ‘smart’ biobots are an interesting
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avenue to duplicate the function of cells responsible for repair and adaptation. 
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One of the tools that eukaryotic cells have at their disposal to detect their surroundings are heterodimeric sensor
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molecules present on the cell surface, known as integrins.  Not only do integrins receive and facilitate cellular integration
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of extracellular cues, but they also support inside-out signaling and thus can dynamically impact their microenvironment.
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As a consequence of integrin’s critical role in this cell-ECM “dynamic reciprocity”, they represent the ideal sensor to build
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into a biobot.  Synthetic biology applications are traditionally performed in the bacterial systems due to their availability,
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convenience, and speed. In order to complete our goal of expressing human integrins on the surface of bacterial cells,
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we will need a variety of lab and research materials necessary to experiment with the cells and eventually incorporate the
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integrins onto them. We will then need a way to test the effectiveness of the integrins on the cells. All funds given to us will
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help cover our lab material expenses.
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{|
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|align="center"|[[Team:GeorgiaTech | Team GeorgiaTech]]
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<!--- The Mission, Experiments --->
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{| style="color:#1b2c8a;background-color:#0c6;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="62%" align="center"
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!align="center"|[[Team:GeorgiaTech|Home]]
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!align="center"|[[Team:GeorgiaTech/Team|Team]]
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!align="center"|[https://igem.org/Team.cgi?year=2013&team_name=GeorgiaTech Official Team Profile]
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!align="center"|[[Team:GeorgiaTech/Project|Project]]
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!align="center"|[[Team:GeorgiaTech/Parts|Parts Submitted to the Registry]]
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!align="center"|[[Team:GeorgiaTech/Modeling|Modeling]]
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!align="center"|[[Team:GeorgiaTech/Notebook|Notebook]]
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!align="center"|[[Team:GeorgiaTech/Safety|Safety]]
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!align="center"|[[Team:GeorgiaTech/Attributions|Attributions]]
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Latest revision as of 02:35, 27 October 2013

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