Team:Kyoto

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Revision as of 02:00, 6 September 2013

Every organism has its own cycle such as the periodicity of cell division, ordered patterns of its body. Some kinds of the cycles are known to be regulated just by two factors. Using E. coli, we applied this principle at intracellular and intercellular levels.

Firstly, we focused on oscillation regulated by RNA. We suspected that if RNA world hypothesis is correct, there could be intracellular oscillatory system without any protein. To show the possibility of cycle formation by RNA, we constructed an oscillator based on the principle by utilizing two different types of functional RNA, which are transcriptional activator and repressor.

Secondly, we also targeted on planar oscillation forming mechanism. A. Turing (1952) suggested a simple principle containing just two variables explains many organisms’ epidermal pattern formation. However, it is not confirmed the pattern formation is only based on Turing’s discourses. To check this, we used two types of E. coli, which secrete different factors, and regulated their population.

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-Every organism has various cycles such as repeated cell division, and ordered patterns of the animals' body. These cycles can be made just by two factors. Using E. coli, we tried to check this principle at intracellular and intercellular levels.
+<p>Every organism has its own cycle such as the periodicity of cell division, ordered patterns of its body. Some kinds of the cycles are known to be regulated just by two factors. Using E. coli, we applied this principle at intracellular and intercellular levels.</p>
-Firstly, some researchers propose RNA world hypothesis. Then, did an oscillatory regulation system of RNA function exist in RNA world? To show the possibility of cycle formation by RNA, we tried to construct an oscillator based on the principle by utilizing two different types of functional RNA, which are transcriptional activator and repressor (RNA oscillator).
-Secondly, Turing, a famous mathematician suggests that some of the animals’ body patterns (Turing Pattern) obey the principle. However, it's not certain if the organisms can make their pattern just by this principle. To check this, we used two types of E. coli, which secrete different factors, and regulated their population.
+<p>Firstly, we focused on oscillation regulated by RNA. We suspected that if RNA world hypothesis is correct, there could be intracellular oscillatory system without any protein. To show the possibility of cycle formation by RNA, we constructed an oscillator based on the principle by utilizing two different types of functional RNA, which are transcriptional activator and repressor.</p>
+<p>Secondly, we also targeted on planar oscillation forming mechanism. A. Turing (1952) suggested a simple principle containing just two variables explains many organisms’ epidermal pattern formation. However, it is not confirmed the pattern formation is only based on Turing’s discourses. To check this, we used two types of E. coli, which secrete different factors, and regulated their population.</p>
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