Team:UCL/Project/Circuit

From 2013.igem.org

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Revision as of 15:22, 4 September 2013

CIRCUIT OVERVIEW

IGEM: Intelligently Genetically Engineered Microglia

Our ambitious project [internal link to PROJECT main sub-page] concerns bringing synthetic biology to the brain in order to try a novel approach to tackling Alzheimer’s Disease [internal link to Alzheimer’s disease]. Microglia [internal link to microglia] are mobile brain cells, making them an ideal chassis [internal link to chassis]. To do this, our proposed treatment would involve extracting microglia from a patient, or using a specially bred immortalised line of human microglia, to avoid rejection, and transfecting it with our new genetic circuit. Implantation into the brain could be performed surgically or using a viral vector - but in order to better control the numbers of genetically engineered microglia (GEM) in the brain micro-neurosurgery may prove best. Our circuit is designed to detect [internal link to detection] amyloid plaques [internal link to neuropathology], attract other microglia, degrade [internal link to degradation] the plaques, reduce [internal link to future directions] neuroinflammation and support [internal link to future direction] dying neurons. Theoretically [internal link to neuropathology], this should halt the progression of Alzheimer’s disease and could lead to other forms of neuro-genetic engineering [internal link to Human Practice main sub-page].

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 <p class="minor_title">IGEM: Intelligently Genetically Engineered Microglia</p>
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-Lorem ipsum dolor sit amet, consectetur adipiscing elit. Vivamus vel fringilla diam. Integer placerat sapien sed risus mollis, eget hendrerit lorem tincidunt. Cras a sem eros. Ut nec ligula eget tortor ornare tempus sit amet quis risus. Quisque condimentum, ipsum ac rhoncus ornare, tellus augue imperdiet libero, in venenatis justo arcu quis tellus. Vivamus magna libero, tempus ac augue at, placerat vulputate nunc. Praesent fringilla id erat ut sagittis. Sed nec semper risus, nec condimentum leo. Vestibulum pharetra pellentesque augue, non ultrices leo varius et. Vestibulum id egestas orci. Vestibulum metus ipsum, iaculis nec sapien in, fringilla cursus orci. Class aptent taciti sociosqu ad litora torquent per conubia nostra, per inceptos himenaeos. Curabitur eget vulputate ligula. Sed venenatis nulla et porta pharetra. Suspendisse pharetra suscipit justo sagittis consequat. Morbi eu iaculis diam, ac rhoncus urna. Pellentesque eros ligula, mollis vitae metus sit amet, interdum gravida nunc. Duis tempor quam id rhoncus sodales. Nunc commodo accumsan orci ut faucibus. Quisque vitae luctus libero. Nullam risus libero, convallis et viverra sit amet, convallis a neque. Integer adipiscing ac arcu sit amet luctus. In dignissim mauris non justo tempor, in rhoncus augue volutpat. Duis euismod sodales blandit. Vivamus volutpat molestie dignissim. Quisque cursus quam cursus dui faucibus convallis. Praesent dignissim, sem ut posuere accumsan, libero diam consequat libero, vel tempor dui mi sed massa. Aenean eros arcu, sollicitudin a euismod eu, placerat vel nunc. Nunc consequat blandit fermentum. Curabitur ante erat, lobortis ac faucibus a, sollicitudin egestas nisi. Morbi ut dolor scelerisque, fermentum est vitae, commodo tortor. Vestibulum ornare semper lorem vel volutpat. In erat ligula, auctor eu pellentesque vitae, sollicitudin id sapien. Duis pharetra sagittis purus hendrerit pharetra. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Vivamus elementum iaculis neque nec fringilla. Nunc a scelerisque nulla, et varius massa. In eu pretium eros. Quisque nec lacus elit. Mauris malesuada luctus dapibus. Vivamus eget ultricies sem. Quisque nulla tellus, euismod vel vehicula adipiscing, ornare sit amet dui. Sed eget mauris aliquam, feugiat diam vel, lacinia nunc. Ut vel est facilisis, dictum sem sit amet, lobortis arcu. In hac habitasse platea dictumst. Fusce ut accumsan sapien. Sed pharetra ullamcorper dolor vitae rutrum. Aliquam luctus mattis felis vitae semper. Vivamus id sodales purus. Cras quis quam non tortor tincidunt laoreet varius suscipit lectus. Curabitur faucibus et libero quis vulputate. Nunc sed gravida libero. Phasellus eleifend, metus mattis molestie luctus, augue libero lacinia massa, ac volutpat tortor tortor quis sapien. Donec ultrices felis ut arcu rutrum sollicitudin. Praesent nec ligula at risus hendrerit aliquam. Etiam vestibulum aliquam ultricies. Ut semper libero volutpat, rutrum enim et, eleifend nibh. Nulla ornare, elit sed laoreet condimentum, quam nunc auctor sem, eu commodo elit ante id magna.
+Our ambitious project [internal link to PROJECT main sub-page]  concerns bringing synthetic biology to the brain in order to try a novel approach to tackling Alzheimer’s Disease [internal link to Alzheimer’s disease]. Microglia [internal link to microglia] are mobile brain cells, making them an ideal chassis [internal link to chassis]. To do this, our proposed treatment would involve extracting microglia from a patient, or using a specially bred immortalised line of human microglia, to avoid rejection, and transfecting it with our new genetic circuit. Implantation into the brain could be performed surgically or using a viral vector - but in order to better control the numbers of genetically engineered microglia (GEM) in the brain micro-neurosurgery may prove best. Our circuit is designed to detect [internal link to detection] amyloid plaques [internal link to neuropathology], attract other microglia, degrade [internal link to degradation] the plaques, reduce [internal link to future directions] neuroinflammation and support [internal link to future direction] dying neurons. Theoretically [internal link to neuropathology], this should halt the progression of Alzheimer’s disease and could lead to other forms of neuro-genetic engineering [internal link to Human Practice main sub-page].
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