Team:Ciencias-UNAM/Project/GeneralDesign

From 2013.igem.org

(Difference between revisions)
Line 212: Line 212:
<br>
<br>
(aquí va la imagen)
(aquí va la imagen)
-
</span></p>
 
-
 
-
style:normal;text-decoration:none;color:#666666;">
 
-
 
-
<b>Antimicrobial Peptide</b> System
 
-
 
-
</span></p>
 
-
<span style="font-family:Arial;font-size:13px;font-weight:normal;font-style:normal;text-decoration:none;color:#666666;">
 
-
 
-
<br>
 
-
The protagonist of this celebration is Death itself.  Death has different names (curiously enough, all of them feminine) which include: <i>La Parca</i>, <i>La Huesuda</i>, <i>La Calaca</i>, <i>La Calavera</i> and <i>La Catrina</i> (this last one is a name that Diego Rivera gave to a famous zinc etching by Jose Guadalupe Posada, portraying an <i>“elegant skull”</i>)
 
-
<br>
 
-
An interesting characteristic of  <i>La Catrina</i> is that she serves as an intermediary in the death of a “chosen one”, meaning it only takes a specific victim. Our synthetic design intends to modify a bacteria so it can go after specific pathogenic bacteria <i>in vivo</i>. We though of the name <i>Skully coli</i>  as a fun cultural analogy that also describes the intention of our system. <br>
 
-
<br>
 
-
(imagen de la catrina)
 
-
 
</span></p>
</span></p>

Revision as of 21:39, 26 September 2013

General Design

HOME

PROJECT

HUMAN PRACTICES

TEAM

SAFETY

Home > Project > General Design

General Design


Our design has two systems:
The Antimicrobial Peptide System, which produces the peptide LL-37; and
The Resistance and Expulsion System which produces the MarA protein, which activates the arcAB & TolC operons, activating the arcAB & TolC efflux pump.

(aquí va la imagen)

 

Why Skully coli?

Mexican culture has an interesting relationship with death. There’s a holiday called The Day of the Death, (or Día de muertos in Spanish) in which the deceased are celebrated with colorfully decorated altars with sugar skulls, food, beverages and some of the favorite belongings of the deceased.

The protagonist of this celebration is Death itself. Death has different names (curiously enough, all of them feminine) which include: La Parca, La Huesuda, La Calaca, La Calavera and La Catrina (this last one is a name that Diego Rivera gave to a famous zinc etching by Jose Guadalupe Posada, portraying an “elegant skull”)

An interesting characteristic of La Catrina is that she serves as an intermediary in the death of a “chosen one”, meaning it only takes a specific victim. Our synthetic design intends to modify a bacteria so it can go after specific pathogenic bacteria in vivo. We though of the name Skully coli as a fun cultural analogy that also describes the intention of our system.

(imagen de la catrina)

PROJECT MENU

Overview

General Design

Wet Lab

BioBricks

Results

Characterization

Protocols

Dry Lab

Modelling

Conclusions

Future Work

References

Retrieved from "http://2013.igem.org/Team:Ciencias-UNAM/Project/GeneralDesign"