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| - | <div id="bronzemedal" class="medal" style="text-align: center";><h8><b>Bronze Medal </b> Requirements</h8>
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| - | <p>Team is registered! <a href="https://2013.igem.org/Team:Heidelberg/Team" class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px;" data-trigger='click', data-title="iGEM Team Heidelberg", data-content='The Team Heidelberg is finally back in the iGEM competition this year. If you want to know more about our team visit our team-page! Link zum Team-Page'>
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| - | <p> Judging form is completed and submitted! <span href="#" class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px;" data-trigger='click', data-title="Judging form", data-content='Our judging form was filled in and is available online.'> </p></span>
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| - | <p> Project description of the Philosopher's Stone online! <span href="#" class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px;" data-trigger='click', data-title="Project description", data-content='Numerous non-ribosomal peptides such as antibiotics, chelators of metals, dyes and detoxificating enzymes are produced in an alternative ribosome-independent pathway as secondary metabolites, found in fungi and various bacteria. The chain of modules the enzyme - called non-ribosomal peptide synthetase (NRPS) - consists of, subsequently adds a defined amino acid to build a template-independent peptide chain. Every module’s sequence of subdomains furthermore encodes for possible chemical modifications of the amino acid. <br/><br/>We will investigate modularity of the NRPS systems giving rise to the assembly of novel, engineered synthetases and subsequent synthesis of artificial non-ribosomal peptides. Currently, we are establishing the introduction of different NRPS pathways into E. coli. Our aim is to prove interchangeability of NRPS modules and domains from different host organisms. Smaller peptide synthetases, e.g. producing dyes, are used for the exchange of domains, whereas more complex synthetases, e.g. producing antibiotics, were chosen to investigate module exchangeability.<br/><br/> We wish to share the enormous potential of non-ribosomal peptide synthetases with the iGEM community by establishing a standard system for these synthetases, supported by an implemented software framework. Thereby, we are going to simplify manufacturing and applicability of non-ribosomal peptides in order to offer a cost- and energy-efficient alternative for the synthesis of biomolecules. As secondary metabolites, these peptides play important roles in basic research (such as dyes), pharmaceutical development (such as antibiotics) and recycling (such as chelators). '>
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| - | <p> Poster is prepared for the European Jamboree in Lyon! <span href="#" class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right"style="font-size: 11px;" data-trigger='click', data-title="Poster presentation at European jamboree", data-content='We are looking forward to see you at the poster presentation!'>
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| - | <p> New standard BioBrick is documented! <span href="#" class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px;" data-trigger='click', data-title="New standard Biobrick", data-content='We did not only add one, but 20 parts to the registry. Feel free to browse the parts we offer the community. Link zur partsseite....'>
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| - | <div id="silvermedal" class="medal" style="text-align: center";><h8><b>Silver Medal </b> Requirements
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| - | <p> New BioBricks are characterized! <span href="#" class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px;"data-trigger='click', data-title="New characterized Biobricks", data-content='We characterized our new BioBricks experimentally and documented our findings in the parts registry: Link zu partsregistry'></p></span><br/>
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| - | <p> New BioBricks are submitted! <span href="#" class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px;"data-trigger='click', data-title="New submitted Biobricks", data-content='We submitted 20 parts to the parts registry - ranging from the basis for a NRPS-module library, to novel NRPSs and constructs, where entirely synthetic protein-domains were introduced. Link zur parts seite'></p></span><br/>
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| - | <p> Implications for ethics are pointed out! <span href="#" class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px;"data-trigger='click', data-title="Project`s implications", data-content='At the beginning of the project, we pointed out possible ethical implications in an essay. (bei essay)Link zum Essay von Philipp. '></p></span>
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| - | <div id="goldmedal" class="medal" style="text-align:center" ><h8><b>Gold Medal </b> Requirements</h8><br/>
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| - | <p> Functions of existing BioBricks were improved! <span href="#" class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px;"data-trigger='click', data-title="Improved BioBricks", data-content='Functions of three existing BioBricks were improved: <br/> <br/> 1) We annotated the PPTase on [Part, link zur registry]. By submitting additional PPTases to the parts registry, we expanded apllications of PPTases. <br/> <br/> 2) We identified a missing sequence in the backbone pSB4K5 from the spring distribution of 2012. <br/><br/> 3) We further characterized the toxicity of [Part, link zur registry], an exporter in <i>E. coli</i>. '></p> </span><br/>
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| - | <p> We helped other iGEM teams! <span href="#" class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px;"data-trigger='click', data-title="Collaboration", data-content='In the past months, we collaborated with other student iGEM teams: We sent Freiburg a eukaryotic cell line. Norwich received soil samples from the beautiful forests of Heidelberg and we helped Purdue by participating in their survey. Additionally, we fixed a bug in Cambridge's Gibthon software tool. The parts registry is now properly connected to Gibthon and importing parts directly from the registry is possible (if they accept our pull request on GitHub).'></p> </span><br/>
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| - | <p> Novel approach to ownership and sharing is described!<span class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px;"data-trigger='click', data-title="NRPS-Designer", data-content='With the NRPS Designer we share with the iGEM community is a novel approach to ownership and sharing in synthetic biology. Visit our NRPS Designer and try it yourself.'></p> </span> <br/><br/><br/><br/><br/><br/><br/><br/><br/><br/>
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| - | <div id="best" class="medal"><h8><b>Best New Standard</b></h8>
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| - | <p> Improve the function of an existing BioBrick Part or Device <span class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px;margin-right:60%;"data-trigger='click', data-title="Non-ribosomal peptide synthetase", data-content='Please explain briefly why you should receive any of these special prizes:'></p> </span>
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| - | <div id="parts" class="medal" ><h8 ><b>Parts!</b></h8>
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| - | <p>Have a look on our different parts! <span class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px;margin-right:60%;"data-trigger='click', data-title="Non-ribosomal peptide synthetase", data-content='Link to our parts? '></p> </span>
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| - | <div id="attribution" class="medal"><h8><b>Attribution and Contribution!</b></h8>
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| - | <p> Thank you for the great help! <span class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px; margin-right:60%;" data-trigger='click', data-title="...", data-content='Link to sponsors and other donors of stuff and time... '></p></span>
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| - | <h1><span style="font-size:150%;color:#FFCC00;">iGEM Medals</span><span class="text-muted" style="font-size:90%"> for Software Teams</span></h1>
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| - | <div id="bronzemedal" class="medal" style="text-align: center";><h8><b>Bronze Medal </b> Requirements</h8>
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| - | <p>Team is registered! <span class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px;" data-trigger='click', data-title="iGEM Team Heidelberg", data-content='The Team Heidelberg is registered but not as software team...'>
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| - | <p> Judging form is completed and submitted! <span href="#" class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px;" data-trigger='click', data-title="Judging form", data-content='Our judging form was filled in and is available online.'> </p></span>
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| - | <p> Project description of the Philosopher's Stone online! <span href="#" class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px;" data-trigger='click', data-title="Project description", data-content='Numerous non-ribosomal peptides such as antibiotics, chelators of metals, dyes and detoxificating enzymes are produced in an alternative ribosome-independent pathway as secondary metabolites, found in fungi and various bacteria. The chain of modules the enzyme - called non-ribosomal peptide synthetase (NRPS) - consists of, subsequently adds a defined amino acid to build a template-independent peptide chain. Every module’s sequence of subdomains furthermore encodes for possible chemical modifications of the amino acid. <br/><br/>We will investigate modularity of the NRPS systems giving rise to the assembly of novel, engineered synthetases and subsequent synthesis of artificial non-ribosomal peptides. Currently, we are establishing the introduction of different NRPS pathways into E. coli. Our aim is to prove interchangeability of NRPS modules and domains from different host organisms. Smaller peptide synthetases, e.g. producing dyes, are used for the exchange of domains, whereas more complex synthetases, e.g. producing antibiotics, were chosen to investigate module exchangeability.<br/><br/> We wish to share the enormous potential of non-ribosomal peptide synthetases with the iGEM community by establishing a standard system for these synthetases, supported by an implemented software framework. Thereby, we are going to simplify manufacturing and applicability of non-ribosomal peptides in order to offer a cost- and energy-efficient alternative for the synthesis of biomolecules. As secondary metabolites, these peptides play important roles in basic research (such as dyes), pharmaceutical development (such as antibiotics) and recycling (such as chelators). '>
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| - | <p> Poster is prepared for the European Jamboree in Lyon! <span href="#" class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right"style="font-size: 11px;" data-trigger='click', data-title="Poster presentation at European jamboree", data-content='We are looking forward to see you at the poster presentation!'>
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| - | <p> Develop and make available via the The Registry of Software Tools an open source software tool that supports synthetic biology based on BioBrick standard biological parts<span href="#" class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px;" data-trigger='click', data-title="New standard Biobrick", data-content='We did not only add one, but 20 parts to the registry. Feel free to browse the parts we offer the community. Link zur partsseite....'>
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| - | <div id="silvermedal" class="medal" style="text-align: center";><h8><b>Silver Medal </b> Requirements
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| - | <p> Provide a detailed, draft specification for the next version of your software tool<span href="#" class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px;"data-trigger='click', data-title="New characterized Biobricks", data-content='We characterized our new BioBricks experimentally and documented our findings in the parts registry: Link zu partsregistry'></p></span><br/>
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| - | <p> Provide a second, distinct (yet complementary) software tools project<span href="#" class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px;"data-trigger='click', data-title="New submitted Biobricks", data-content='We submitted 20 parts to the parts registry - ranging from the basis for a NRPS-module library, to novel NRPSs and constructs, where entirely synthetic protein-domains were introduced. Link zur parts seite'></p></span><br/>
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| - | <p> Provide a demonstration of their software either as a textual or video tutorial made available on their wiki. This tutorial should explain all the features of the tool as well as provide sample input and output as appropriate. <span href="#" class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px;"data-trigger='click', data-title="Project`s implications", data-content='At the beginning of the project, we pointed out possible ethical implications in an essay. (bei essay)Link zum Essay von Philipp. '></p></span>
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| - | <div id="goldmedal" class="medal" style="text-align:center" ><h8><b>Gold Medal </b> Requirements</h8><br/>
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| - | <p> Have another team utilize the software developed by your team.<span href="#" class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px;"data-trigger='click', data-title="Improved BioBricks", data-content='Functions of three existing BioBricks were improved: <br/> <br/> 1) We annotated the PPTase on [Part, link zur registry]. By submitting additional PPTases to the parts registry, we expanded apllications of PPTases. <br/> <br/> 2) We identified a missing sequence in the backbone pSB4K5 from the spring distribution of 2012. <br/><br/> 3) We further characterized the toxicity of [Part, link zur registry], an exporter in <i>E. coli</i>. '></p> </span><br/>
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| - | <p> team may instead use SBOL in your software documentation.<span href="#" class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px;"data-trigger='click', data-title="Collaboration", data-content='In the past months, we collaborated with other student iGEM teams: We sent Freiburg a eukaryotic cell line. Norwich received soil samples from the beautiful forests of Heidelberg and we helped Purdue by participating in their survey. Additionally, we fixed a bug in Cambridge's Gibthon software tool. The parts registry is now properly connected to Gibthon and importing parts directly from the registry is possible (if they accept our pull request on GitHub).'></p> </span><br/>
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| - | <p> Develop and document a new technical standard<span class="btn btn-default btn-lg medal-requirement glyphicon glyphicon-hand-right" style="font-size: 11px;"data-trigger='click', data-title="NRPS-Designer", data-content='With the NRPS Designer we share with the iGEM community is a novel approach to ownership and sharing in synthetic biology. Visit our NRPS Designer and try it yourself.'></p> </span> <br/><br/><br/><br/><br/><br/><br/><br/><br/><br/>
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iGEM Medals for Non-Software Teams
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