Team:Hong Kong CUHK/ianda
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+ | <h1>Prof. Kong Siu-Kai</h1> | ||
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+ | <p>Our laboratory studies the process of apoptosis. During apoptosis, enzymes such as caspase become active and orchestrate the death of the cell. One mechanism of caspase activation involves the release of cytochrome c and other apoptosis-inducing factors from damaging mitochondria.</p> | ||
+ | <p>In particular, we are interested in elucidating how mitochondria regulate the apoptosis in 'normal' and drug-resistant cancer cells. We are wondering how the resistance of mitochondria to MMP can explain the resistance of cancer cells to apoptosis induction, and we hope to develop strategies for overcoming chemotherapy resistance by targeting tumor mitochondria. We believe that pharmacological interventions on mitochondria are good strategies to promote cell death in tumor cells. This research topic on apoptosis is therefore relevant to disease treatment with socioeconomic impacts.</p> | ||
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Revision as of 01:10, 29 October 2013