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Team:MIT
From 2013.igem.org
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<h1>Motivation</h1> | <h1>Motivation</h1> | ||
| - | <p>This summer, the 2013 MIT iGEM team worked to engineer exosome mediated cell | + | <p>This summer, the 2013 MIT iGEM team worked to engineer exosome mediated cell-cell communication. In vivo cell-cell communication is vital for pattern formation, organ development, coordinated responses to environmental changes, and the maintenance of an organism (Bacchus, 2012)</p> |
<h1>Our Contribution</h1> | <h1>Our Contribution</h1> | ||
| - | <p>The 2013 MIT iGEM demonstrated that exosomes can be engineered to transport protein and miRNA signals of interest that can actuate a response in a receiver cell. | + | <p>The 2013 MIT iGEM demonstrated that exosomes can be engineered to transport protein and miRNA signals of interest that can actuate a response in a receiver cell. By co-culturing sender and receiver cells we have demonstrated on way cell-cell communication. </p> |
<h1>Our Vision</h1> | <h1>Our Vision</h1> | ||
| - | <p>One exciting application of engineered cell-cell | + | <p> The MIT iGEM teams believes that exosomal communication is an innovative means of engineering cell-cell communication. One exciting application of engineered cell-cell communication is in drug testing and development: tissue engineers are currently working to develop organoids (Lancaster, 2013) small tissue structures that recapitulate the behavior of organs in vitro. Organoids can be used to test drugs more rigorously in a human-like context rather than relying solely on animal models. Thus drugs can be developed with a better understanding of their toxicity and efficacy.<p> |
<p> Lancaster, Madeline et al. Cerebral organoids model human brain development and microcephaly. Nature 501, 373–379 (2013) | <p> Lancaster, Madeline et al. Cerebral organoids model human brain development and microcephaly. Nature 501, 373–379 (2013) | ||
Revision as of 03:35, 29 October 2013
Motivation
This summer, the 2013 MIT iGEM team worked to engineer exosome mediated cell-cell communication. In vivo cell-cell communication is vital for pattern formation, organ development, coordinated responses to environmental changes, and the maintenance of an organism (Bacchus, 2012)
Our Contribution
The 2013 MIT iGEM demonstrated that exosomes can be engineered to transport protein and miRNA signals of interest that can actuate a response in a receiver cell. By co-culturing sender and receiver cells we have demonstrated on way cell-cell communication.
Our Vision
The MIT iGEM teams believes that exosomal communication is an innovative means of engineering cell-cell communication. One exciting application of engineered cell-cell communication is in drug testing and development: tissue engineers are currently working to develop organoids (Lancaster, 2013) small tissue structures that recapitulate the behavior of organs in vitro. Organoids can be used to test drugs more rigorously in a human-like context rather than relying solely on animal models. Thus drugs can be developed with a better understanding of their toxicity and efficacy.
Lancaster, Madeline et al. Cerebral organoids model human brain development and microcephaly. Nature 501, 373–379 (2013)
