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Team:Evry/Model1
From 2013.igem.org
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<p> | <p> | ||
| - | <span style="color:#0000FF;">A</span> | + | <span style="color:#0000FF;">A</span> : Total quantity of iron absorbed by the duodenum (mol) |
<br/> | <br/> | ||
| - | <span style="color:#FF0000;">S</span> | + | <span style="color:#FF0000;">S</span> : Quantity of solved iron (mol) |
<br/> | <br/> | ||
| - | P | + | P : Total quantity of enterobactin produced by our population of bacteria (mol) |
<br/> | <br/> | ||
| - | <span style="color:#00FFFF;">Q</span> | + | <span style="color:#00FFFF;">Q</span> : Total quantity of chelated iron (mol) |
<br/> | <br/> | ||
| - | N | + | N : Number of bacteria |
</p> | </p> | ||
<img src="https://static.igem.org/mediawiki/2013/1/1d/GrapheRaisonnementModele1.png" alt="text to print if image not found" width=800px /> | <img src="https://static.igem.org/mediawiki/2013/1/1d/GrapheRaisonnementModele1.png" alt="text to print if image not found" width=800px /> | ||
Revision as of 16:36, 4 August 2013
Model 1
Overview
This model simulates the behaviour of a hemochromatosis suffering person's duodenum. We compute the quantity of iron absorbed by the organism. Our genetically modified bacterias are also released in the duodenum and produce siderophores to chelate the solved iron, thus making it unavailable for intestinal absorption.
Assumptions
blaModel Description
blaEquation System
A : Total quantity of iron absorbed by the duodenum (mol)
S : Quantity of solved iron (mol)
P : Total quantity of enterobactin produced by our population of bacteria (mol)
Q : Total quantity of chelated iron (mol)
N : Number of bacteria
Results
blaConclusion
blaReferences:
- Computational Modeling and Simulation of the Human Duodenum - B. Hari, S. Bakalis, P. Fryer - 2012
