Team:Stanford-Brown
From 2013.igem.org
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BioWires - We seek to utilize recent advances in nucleic acid chemistry to replace hydrogen bonds between mismatched DNA bases with cations. A kelation event has been described for mismatched pyrimidines, and we have selected a C-Ag+-C bond for silver's uniquely powerful conductivity. We will rigorously test the structural and thermodynamic properties of this bonding system. Our hope is to show that silver kelation by cytosine mismatches is able to enhance the conductivity of DNA. By engineering cytosine mismatches into synthetic oligonucleotide duplexes, we seek to establish a reliable platform for nanowire and nanodevice assembly. We will design and test various nucleic acid secondary structures, and hope to ultimately produce a DNA-based nanowire system that is conductive enough to be utilized in microchip design and other bioengineering applications. | BioWires - We seek to utilize recent advances in nucleic acid chemistry to replace hydrogen bonds between mismatched DNA bases with cations. A kelation event has been described for mismatched pyrimidines, and we have selected a C-Ag+-C bond for silver's uniquely powerful conductivity. We will rigorously test the structural and thermodynamic properties of this bonding system. Our hope is to show that silver kelation by cytosine mismatches is able to enhance the conductivity of DNA. By engineering cytosine mismatches into synthetic oligonucleotide duplexes, we seek to establish a reliable platform for nanowire and nanodevice assembly. We will design and test various nucleic acid secondary structures, and hope to ultimately produce a DNA-based nanowire system that is conductive enough to be utilized in microchip design and other bioengineering applications. | ||
Revision as of 06:35, 9 August 2013
Stanford-Brown iGEM
Project Descriptions:BioWires - We seek to utilize recent advances in nucleic acid chemistry to replace hydrogen bonds between mismatched DNA bases with cations. A kelation event has been described for mismatched pyrimidines, and we have selected a C-Ag+-C bond for silver's uniquely powerful conductivity. We will rigorously test the structural and thermodynamic properties of this bonding system. Our hope is to show that silver kelation by cytosine mismatches is able to enhance the conductivity of DNA. By engineering cytosine mismatches into synthetic oligonucleotide duplexes, we seek to establish a reliable platform for nanowire and nanodevice assembly. We will design and test various nucleic acid secondary structures, and hope to ultimately produce a DNA-based nanowire system that is conductive enough to be utilized in microchip design and other bioengineering applications.
Team
Who are we?
Data Page
Click here to see a summary of all our data collected so far!
Notebook
Here is a record of our summer's work. We also want to thank everybody who helped us along the way!
The Concept
The concept
Human Practices
Human Practices
Initiative
Initiative
Interviews
Interviews
Design Considerations
Design Considerations
Killswitch
Kill Switch
Safety
Safety
Community Outreach
Community Outreach
Project #1
Project #1
Detecting
Project #1 Detection
Reporting
Project #1 Reporting
Modelling
Modelling for Project #1
Prototyping
Prototyping for Project #1
Project #2
Project #2
Decarboxylation
Project #2
Catechol Degradation
Project #2
Flux-Variability Analysis
Project #2
Bioreactor
Project #2
Upgrading
Project #2