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Team:Ciencias-UNAM
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| - | <div id="u54_rtf"><p style="text-align:left;"><span style="font-family:Arial;font-size:13px;font-weight:normal;font-style:normal;text-decoration:none;color:#666666;">We designed a synthetic system in <i>E. coli</i> to express an antimicrobial peptide (Cathelicidin LL-37) <i>in vivo</i> only in the presence of a quorum sensing molecule (AI-2) and expel it with an efflux pump in order to act against targeted gastrointestinal pathogens | + | <div id="u54_rtf"><p style="text-align:left;"><span style="font-family:Arial;font-size:13px;font-weight:normal;font-style:normal;text-decoration:none;color:#666666;">We designed a synthetic system in <i>E. coli</i> to express an antimicrobial peptide (Cathelicidin LL-37) <i>in vivo</i> only in the presence of a quorum sensing molecule (AI-2) and expel it with an efflux pump in order to act against targeted gastrointestinal pathogens.</span></p></div> |
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Revision as of 23:48, 21 September 2013
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We designed a synthetic system in E. coli to express an antimicrobial peptide (Cathelicidin LL-37) in vivo only in the presence of a quorum sensing molecule (AI-2) and expel it with an efflux pump in order to act against targeted gastrointestinal pathogens.
We are the team from Facultad de Ciencias, UNAM in Mexico City. Our team brings together students and teachers from all over the country, with various backgrounds and interests.
We submitted several devices mainly to test and use the following parts:
Cathelicidin LL-37: An antimicrobial peptide against bacterial infection.
MarA: A peptide responsible for an efflux pump in E. coli that is related to its resistance to cathelicidin and similar peptides.
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