Team:Michigan/Modeling

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Optimization of ON:
Optimization of ON:
[[File:InducibleHbifModel7-2.png |347px|center]]
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[https://docs.google.com/document/d/1LewVc-RZQhwpdMyIHFYT9f4rbFrQXvppZOoQjKCZlLM/edit?usp=sharing Inducible Hbif Model (Link)]
=[[Team:Michigan/Modeling/Future Directions|Future Directions]]=
=[[Team:Michigan/Modeling/Future Directions|Future Directions]]=

Revision as of 23:12, 27 September 2013

Xayona Website Template

Overview Introduction Expression Model Switch Model Inducible Hbif Model Future Directions

Contents

Overview

Best model.jpg

Model of Recombinase Expression

Model of the Switch

Model of Inducible Hbif

Introduction

switch modeling

• goals: produce both states of switch, use model to optimize switch

mass action modeling

• what is mass action

• pros of mass action modeling, i.e. why we used it

• form of mass action models/solvability doc

analytical modeling:

• benefits 

   • naturally standardized
   
   • given parameters, it precisely predicts behavior

   • accurately predicts the data needed to determine parameters

   • allows avoidance of numerical errors like rounding

• ERSESCO 

   • equation

   • reduction

   • solution

   • equilibration

   • stabilization

   • calibration

   • optimization

File:Solvability.pdf

Expression Model

Expression.jpg
ExpressionModelFigure.png

Equation:

ExpressionModel1.png

Reduction: None

Solution:

ExpressionModel2.png

Equilibration:

ExpressionModel3.png

Stabilization:

ExpressionModel3-1.png

Calibration:

ExpressionModel4.png
ExpressionModel5.png

Optimization:

ExpressionModel6.png

Switch Model

Switch.jpg
SwitchModelFigure.png

Equation:

SwitchModel1.png
SwitchModel2.png

Reduction:

SwitchModel3.png

Solution:

SwitchModel3-1.png

Equilibration:

SwitchModel4-1.png

Stabilization:

SwitchModel4-2.png

Calibration:

SwitchModel5-1.png
SwitchModel5-2.png

Optimization:

SwitchModel6.png

Switch Model (Link)

Inducible Hbif Model

InducedHbif.jpg
InducibleHbifModelFigure.png

Equation:

InducibleHbifModel1.png
InducibleHbifModel2.png

Reduction:

InducibleHbifModel3.png

Solution:

InducibleHbifModel4.png

Equilibration:

InducibleHbifModel5.png

Stabilization:

InducibleHbifModel5-2.png

Calibration:

InducibleHbifModel6-1.png
InducibleHbifModel6-2.png
InducibleHbifModel6-3.png

Optimization of Hbif:

InducibleHbifModel7-1.png

Optimization of ON:

InducibleHbifModel7-2.png

Inducible Hbif Model (Link)

Future Directions

Data!

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