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Template:Team:Bonn:NetworkData
From 2013.igem.org
(Difference between revisions)
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case 4: | case 4: | ||
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content.i = 4; | content.i = 4; | ||
| - | content.parents=[3] | + | content.parents=[3] |
content.childs=[]; | content.childs=[]; | ||
| - | content.titleShort = "Zymogen"; | + | content.titleShort = "Zymogen-like protein procursors"; |
| - | content.titleLong = ""; | + | content.titleLong = "Cleaving as posttranslational modification"; |
| - | content.summary= ""; | + | content.summary= ""; |
| - | content.text= ""; | + | content.text= "An approach to regulate protein activity is to use posttranslational modification, especially by cleaving off an inactivating part from a translated pro-peptid. A change of conformation leads to the functional protein. The cleaving can be effected by enzymatic proteolysis, autoproteolysis or surrounding conditions (e.g. pH).</br> A simple example is the activation of pepsinogen which is caused by a low pH (fig. 1). </br> It is a powerful system to activate proteins, which is frequently used in nature and science. Unfortunately posttranslational cleaving can usually not be reversed. Once activated the inactive pro-form of the protein cannot be restored."; |
content.type="Background"; | content.type="Background"; | ||
break; | break; | ||
Revision as of 22:33, 1 October 2013
