Team:Bonn/Project/

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~~</html>~~

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~~= Overview =~~

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~~Making versatile control of biological machines easily possible for everybody we engineer a system for~~

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~~light dependend control of protein activity per protein degradation.</br>~~

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~~Using the ClpXP protease system of prokaryotes enables degradation of a peptid tag (ssrA) fused~~

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~~protein upon induction with the adaptor protein SspB. Using a Split version of SspB, protein degradation is~~

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~~activated through heterodimerisation of both SspB parts.We utilize light dependent heterodimerisation to eventually obtain light inducible degradation. </br>~~

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~~Modelling of the light dependency of protein degradation will even make simple and accurate control of~~

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~~protein activity for any desired level of activity possible.</br>~~

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~~As a proof of principle we investigate degradation of the fluorescent reporter protein mCherry.</br>~~

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~~</br>~~

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-<div id="networkTop" style="position:absolute;top:150px;height:220px;width:800px;border:1px solid black;z-index:1;">
+<div id="networkTop" style="position:absolute;top:150px;height:220px;width:800px;z-index:1;">
 </div>
-<div id="networkBottom" style="position:absolute;top:370px;left:-80px;height:800px;width:1100px;border:1px solid black;z-index:1;">
+<div id="networkBottom" style="position:absolute;top:370px;left:-80px;height:800px;width:1100px;z-index:1;">
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        <div id="subpage-title"></div>
        <div id="subpage-summary"></div>
-</html>
-= Overview =
-<html>
          <div id="subpage-text">
-            Making versatile control of biological machines easily possible for everybody we engineer a system for
-            light dependend control of protein activity per protein degradation.</br>
-            Using the ClpXP protease system of prokaryotes enables degradation of a peptid tag (ssrA) fused
-            protein upon induction with the adaptor protein SspB. Using a Split version of SspB, protein degradation is
-            activated through heterodimerisation of both SspB parts.We utilize light dependent heterodimerisation to eventually obtain light inducible degradation. </br>
-            Modelling of the light dependency of protein degradation will even make simple and accurate control of
-            protein activity for any desired level of activity possible.</br>
-            As a proof of principle we investigate degradation of the fluorescent reporter protein mCherry.</br>
-        </br>
          </div>
        </div>

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Revision as of 11:54, 3 October 2013