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| - | <!-- *** What falls between these lines is the Alert Box! You can remove it from your pages once you have read and understood the alert *** -->
| + | {{:Team:Evry/template_v1}} |
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| - | You are provided with this team page template with which to start the iGEM season. You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki. You can find some examples <a href="https://2008.igem.org/Help:Template/Examples">HERE</a>.
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| - | <!-- *** End of the alert box *** --> | + | <h1>Overall project</h1> |
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| - | {| style="color:#1b2c8a;background-color:#0c6;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="62%" align="center"
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| - | !align="center"|[[Team:Evry|Home]]
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| - | !align="center"|[[Team:Evry/Team|Team]]
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| - | !align="center"|[https://igem.org/Team.cgi?year=2013&team_name=Evry Official Team Profile]
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| - | !align="center"|[[Team:Evry/Project|Project]]
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| - | !align="center"|[[Team:Evry/Parts|Parts Submitted to the Registry]]
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| - | !align="center"|[[Team:Evry/Modeling|Modeling]]
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| - | !align="center"|[[Team:Evry/Notebook|Notebook]]
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| - | !align="center"|[[Team:Evry/Safety|Safety]]
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| - | !align="center"|[[Team:Evry/Attributions|Attributions]]
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| - | |}
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| - | == '''Overall project''' ==
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| | Hemochromatosis is a genetic disease responsible for an abnormal iron accumulation in blood. This illness is due to a mutation on the HFE protein, which leads to a massive iron absorption by the intestines. As a consequence, the organism starts stocking the iron in tissues causing chronic deficiencies. Nowadays, the only efficient way to treat hemochromatosis is by bleed draining. This treatment is invasive and archaic compared to the actual advances in the medical field. | | Hemochromatosis is a genetic disease responsible for an abnormal iron accumulation in blood. This illness is due to a mutation on the HFE protein, which leads to a massive iron absorption by the intestines. As a consequence, the organism starts stocking the iron in tissues causing chronic deficiencies. Nowadays, the only efficient way to treat hemochromatosis is by bleed draining. This treatment is invasive and archaic compared to the actual advances in the medical field. |
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| | Our goal is to lower the iron absorption from the intestines by using an iron chelating bacteria. The gain will be to decrease the frequency of blood draining process and improve the patients lifestyle. We have two main objectives: developping an iron-sensing promoter and overexpressing the siderophore pathway under the control of iron concentration. | | Our goal is to lower the iron absorption from the intestines by using an iron chelating bacteria. The gain will be to decrease the frequency of blood draining process and improve the patients lifestyle. We have two main objectives: developping an iron-sensing promoter and overexpressing the siderophore pathway under the control of iron concentration. |
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| - | == '''Project Details''' ==
| + | <h1>Project Details</h1> |
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| - | | + | <h2> Part 1 </h2> |
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| - | === Part 1 ===
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| | Bacteria engineering and reversed Fur system for iron sensing | | Bacteria engineering and reversed Fur system for iron sensing |
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| - | === Part 2 ===
| + | <h2> Part 2 </h2> |
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| | Modeling on bacteria interaction with duodenum. | | Modeling on bacteria interaction with duodenum. |
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| - | === The Experiments ===
| + | <h3> The Experiments </h3> |
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| - | === Part 3 ===
| + | <h2> Part 3 >/h2> |
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| - | == '''Results''' ==
| + | <h3>Results</h3> |
Hemochromatosis is a genetic disease responsible for an abnormal iron accumulation in blood. This illness is due to a mutation on the HFE protein, which leads to a massive iron absorption by the intestines. As a consequence, the organism starts stocking the iron in tissues causing chronic deficiencies. Nowadays, the only efficient way to treat hemochromatosis is by bleed draining. This treatment is invasive and archaic compared to the actual advances in the medical field.
Our goal is to lower the iron absorption from the intestines by using an iron chelating bacteria. The gain will be to decrease the frequency of blood draining process and improve the patients lifestyle. We have two main objectives: developping an iron-sensing promoter and overexpressing the siderophore pathway under the control of iron concentration.
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