Team:ATOMS-Turkiye/Project/Module2

From 2013.igem.org

(Difference between revisions)
(Created page with "{{:Team:ATOMS-Turkiye/Templates/Head}} <div class="article"> =Overview= This module is continuation of module 1 and the module mainly consists of specific tumor killer proteins w...")
Line 2: Line 2:
<div class="article">
<div class="article">
=Overview=
=Overview=
-
This module is continuation of module 1 and the module mainly consists of specific tumor killer proteins which are expected to decrease cancer cell proliferation and to induce  apoptosis. We have two specific apoptotic proteins called Apoptin and E4orf4. In our project plan, engineered bacteria secrete these proteins and these tumor killers penetrate into cancer cells to induce apoptosis within the cells. Through cancer cell penetration, cell penetrating peptides called TAT (Transactivating Transcription peptide) and MPG (designed cell penetrating peptide) have critical roles. Cell penetrating peptides fused with Apoptin and E4orf4 selectively kill tumor cells while normal cells remain undamaged. This point of view takes the advantage of synthetic biology and implies a new targeted therapeutic approach in future.  
+
This module mainly consist of specific proteins secreted by enginereed bacteria which act as a tumor killer. Our proteins are e4of4 and apoptin. Following bacterial secretion, spesific proteins penetrate into cancer cells and induce apoptosis within the cells.Also, recent studies have reported  that; apoptin and e4of4 proteins are  succesful at achieving apoptosis and are only cancer spesific. At this point, tumor specificity  is very important because there are risks of damaging healthy cells at contemporary cancer treatment.  In our project, we used mpg and tat peptides for penetrating cancer cells together with spesific proteins and we aimed to decrease growth rate of cancer populations.
</div>
</div>

Revision as of 17:37, 16 May 2014

Overview

This module mainly consist of specific proteins secreted by enginereed bacteria which act as a tumor killer. Our proteins are e4of4 and apoptin. Following bacterial secretion, spesific proteins penetrate into cancer cells and induce apoptosis within the cells.Also, recent studies have reported  that; apoptin and e4of4 proteins are  succesful at achieving apoptosis and are only cancer spesific. At this point, tumor specificity  is very important because there are risks of damaging healthy cells at contemporary cancer treatment.   In our project, we used mpg and tat peptides for penetrating cancer cells together with spesific proteins and we aimed to decrease growth rate of  cancer populations.
Retrieved from "http://2013.igem.org/Team:ATOMS-Turkiye/Project/Module2"