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Team:Evry/Model1
From 2013.igem.org
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<h2>Overview</h2> | <h2>Overview</h2> | ||
| - | <p>This model simulates the behaviour of a hemochromatosis suffering person's duodenum. We use it to compute the quantity of iron absorbed by the organism. Once our genetically modified | + | <p>This model simulates the behaviour of a hemochromatosis suffering person's duodenum. We use it to compute the quantity of iron absorbed by the organism. Once our genetically modified bacteria are released in the duodenum, they produce siderophores to chelate the solved iron, thus making it unavailable for intestinal absorption. Then, <b>they eventually flush out of the duodenum</b>. The main hypothesis in this model is that the bacteria doesn't colonize the duodenum : it only flows through. <br/>The goal of this model is to measure how efficient could this form of treatment be.</p> |
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| - | <li> | + | <li>Our bacteria don't settle in the duodenum</li> |
<li>No iron regulation</li> | <li>No iron regulation</li> | ||
<li>Constant iron flow</li> | <li>Constant iron flow</li> | ||
Revision as of 16:07, 5 August 2013
Model 1
Overview
This model simulates the behaviour of a hemochromatosis suffering person's duodenum. We use it to compute the quantity of iron absorbed by the organism. Once our genetically modified bacteria are released in the duodenum, they produce siderophores to chelate the solved iron, thus making it unavailable for intestinal absorption. Then, they eventually flush out of the duodenum. The main hypothesis in this model is that the bacteria doesn't colonize the duodenum : it only flows through.
The goal of this model is to measure how efficient could this form of treatment be.
Assumptions
- Our bacteria don't settle in the duodenum
- No iron regulation
- Constant iron flow
- Homogeneous fluid
- The bacterial quantity is constant
- The bacterial natural absorption is insignificant compared to the chelation
Model Description
blaEquation System
A : Total quantity of iron absorbed by the duodenum (mol)
S : Quantity of solved iron (mol)
P : Total quantity of enterobactin produced by our population of bacteria (mol)
Q : Total quantity of chelated iron (mol)
N : Number of bacteria
Results
blaConclusion
It is possible to reduce intestinal iron intake up to 50% if the patient takes one pill during each meal. This means that the patient would endure a lighter treatment : less bloodletting for people suffering from hemochromatosis, and less iron chelator's side effects for the thalassemia.
References:
- Computational Modeling and Simulation of the Human Duodenum - B. Hari, S. Bakalis, P. Fryer - 2012
