|
|
Line 254: |
Line 254: |
| <a id="four" href="#third-section"><li><img src="http://c.dryicons.com/images/icon_sets/symbolize_icons_set/png/128x128/chart.png"/></li></a> | | <a id="four" href="#third-section"><li><img src="http://c.dryicons.com/images/icon_sets/symbolize_icons_set/png/128x128/chart.png"/></li></a> |
| </ul> | | </ul> |
- | </div> | + | </div> |
- | | + | |
- | <!--<div id="top">-->
| + | |
- |
| + | |
- | <!--circle buttons in banner-->
| + | |
- | <!--<div class="row" style="position: relative !important;margin-left: auto; margin-right: auto; display: block; width: 600px; max-height: 100px; margin-top: 30px; overflow: hidden; ">
| + | |
- | <a id="two" href="#first-section">
| + | |
- | <div class="span_smaller" style="float: left; margin: 0px 0px 70px 70px; background-image: url('https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/jtmF8YkJ_P/device%20photo.jpg?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg');">
| + | |
- | <h3 style="margin-top:30px; color:#380060">Abstract<h3></div><!-- /.span4 </a>
| + | |
- |
| + | |
- | <!-- <a id="three" href="#second-section"><div class="span_smaller" style="align: center; float: center; margin: 0px 0px 70px 70px; display: inline-block;background-image: url('https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/0RorW85BOS/Lynch%20Labs%20PGFI/BE_LynchLabGroup_DSC2733.jpg?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg'); ">
| + | |
- | <h3 style="margin-top:30px; color:#380060;">Methods</h3></div><!-- /.span4 </a>
| + | |
- |
| + | |
- | <!-- <a id="four" href="#third-section"><div class="span_smaller" style="margin: 0px 0px 70px 70px; background-image: url('https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/FsZxKlaNDL/Screen%20shot%202013-05-31%20at%2015.29.53.png?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg');">
| + | |
- | <h3 style="margin-top:30px; color:#380060;">Results</h3></div><!-- /.span4 </a>
| + | |
- | </div><!--/row-->
| + | |
| | | |
| | | |
- |
| + | |
- | | + | |
- | <!--First section-->
| + | |
- | <div class="section" id="first-section">
| + | |
- |
| + | |
- | <div align="center" class="row" style="position: relative; margin-left: auto; margin-right: auto; display: block; width: 600px; max-height: 200px; margin-top: 140px; margin-bottom: 40px; overflow: hidden; position: static; white-space: nowrap;">
| + | |
- | <div class="span4" style="background-image: url('https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/jtmF8YkJ_P/device%20photo.jpg?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg'); margin: 0px 25px 0px 25px;">
| + | |
- | </div><!-- /.span4 -->
| + | |
- |
| + | |
- | <div class="span4" style="background-image: url('https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/WTlON78GgW/IMG_0264.JPG?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg'); margin: auto; align: center; margin: 0px 25px 0px 25px;">
| + | |
- | <!--<img src="https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/WTlON78GgW/IMG_0264.JPG?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg"/>-->
| + | |
- | </div><!-- /.span4 -->
| + | |
- | | + | |
- | <div class="span4" style="background-image: url('https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/Y5d0PLu26o/photo-7.JPG?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg'); margin: auto; margin: 0px 25px 0px 25px;">
| + | |
- | <!--<img src="https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/APrj2Se2i-/Lynch%20Labs%20PGFI/BE_LynchLabGroup_DSC2811.jpg?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg"/>-->
| + | |
- | </div><!-- /.span4 --></div>
| + | |
| | | |
| | | |
Line 321: |
Line 291: |
| | | |
| | | |
- | <!--<div class="img-span">
| |
- | </div>-->
| |
- |
| |
- | <div class="section" id="second-section">
| |
- |
| |
- | <div align="center" class="row" style="position: relative; margin-left: auto; margin-right: auto; display: block; width: 600px; max-height: 200px; margin-top: 180px; margin-bottom: 40px; overflow: hidden; position: static; white-space: nowrap;">
| |
- | <div class="span4" style="background-image: url('https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/0RorW85BOS/Lynch%20Labs%20PGFI/BE_LynchLabGroup_DSC2733.jpg?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg'); margin: 0px 25px 0px 25px;">
| |
- | </div><!-- /.span4 -->
| |
- | <div class="span4" style="background-image: url('https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/8auH76HSpC/Lynch%20Labs%20PGFI/BE_LynchLabGroup_DSC2721.jpg?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg'); margin: 0px 25px 0px 25px;">
| |
- | <!--<img src="https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/WTlON78GgW/IMG_0264.JPG?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg"/>-->
| |
- | </div><!-- /.span4 -->
| |
- |
| |
- | <div class="span4" style="background-image: url('https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/Cqv03LbbM-/Lynch%20Labs%20PGFI/BE_LynchLabGroup_DSC2809.jpg?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg'); margin: 0px 25px 0px 25px;">
| |
- | <!--<img src="https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/APrj2Se2i-/Lynch%20Labs%20PGFI/BE_LynchLabGroup_DSC2811.jpg?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg"/>-->
| |
- | </div><!-- /.span4 --></div>
| |
- |
| |
- |
| |
- |
| |
- | <!--first hero unit-->
| |
- | <div class="hero-unit" id="text">
| |
- | <div id="icon"> <img src="http://clipartist.info/www/TATARTIST.NET/L/lab_icon_test_tube_2_black_white_line_art_tatoo_tattoo-555px.png"/></div><h4>Methods</h4>
| |
- | <img class="figure" src="https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/jtmF8YkJ_P/device%20photo.jpg?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg"/><p class="caption">This is a caption</p><p>Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor
| |
- | incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud
| |
- | exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. </p>
| |
- | </div>
| |
- | <div class="hero-unit" id="text">
| |
- | <img class="figure" src="https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/FsZxKlaNDL/Screen%20shot%202013-05-31%20at%2015.29.53.png?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg"/>
| |
- | <p>Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor
| |
- | incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud
| |
- | exercitation </p>
| |
- | </div>
| |
- |
| |
- | <div class="hero-unit" id="text">
| |
- | <p>Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor
| |
- | incididunt ut labore et dolore magna aliqua. Ut enim ad minim
| |
- | </p><img class="figure" src="https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/jtmF8YkJ_P/device%20photo.jpg?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg"/>
| |
- | </div>
| |
- | </div><div class="clear"></div>
| |
- |
| |
- |
| |
- | </div>
| |
- |
| |
- |
| |
- | </div>
| |
- |
| |
- | </div> <!--endsection-->
| |
- |
| |
- | </div>
| |
- |
| |
- |
| |
- | <!--<div class="img-span">
| |
- | </div>-->
| |
- |
| |
- | <div class="section" id="third-section">
| |
- |
| |
- | <div align="center" class="row" style="position: relative; margin-left: auto; margin-right: auto; display: block; width: 600px; max-height: 200px; margin-top: 170px; margin-bottom: 40px; overflow: hidden; position: static; white-space: nowrap;">
| |
- | <div class="span4" style="background-image: url('https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/FsZxKlaNDL/Screen%20shot%202013-05-31%20at%2015.29.53.png?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg'); margin: 0px 25px 0px 25px;">
| |
- | </div><!-- /.span4 -->
| |
- | <div class="span4" style="background-image: url('https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/-RV-MArbh8/Screen%20shot%202013-05-29%20at%2016.22.26.png?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg'); margin: 0px 25px 0px 25px;">
| |
- | <!--<img src="https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/WTlON78GgW/IMG_0264.JPG?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg"/>-->
| |
- | </div><!-- /.span4 -->
| |
- |
| |
- | <div class="span4" style="background-image: url('https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/-RV-MArbh8/Screen%20shot%202013-05-29%20at%2016.22.26.png?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg'); margin: 0px 25px 0px 25px;">
| |
- | <!--<img src="https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/APrj2Se2i-/Lynch%20Labs%20PGFI/BE_LynchLabGroup_DSC2811.jpg?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg"/>-->
| |
- | </div><!-- /.span4 --></div>
| |
- |
| |
- |
| |
- |
| |
- | <!--first hero unit-->
| |
- | <div class="hero-unit" id="text">
| |
- | <div id="icon"><img src="http://c.dryicons.com/images/icon_sets/symbolize_icons_set/png/128x128/chart.png"/></div><h4>Results</h4>
| |
- | <p>Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor
| |
- | incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud
| |
- | exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. <img src="https://googledrive.com/host/0B4ZBZOYYKBzEdTRvdHVIRDI0OWM/"
| |
- | class="figure"/><p class="caption">This is a caption</p><p>Duis aute irure dolor
| |
- | in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur
| |
- | sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum</p>
| |
- | <p>Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor
| |
- | incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud
| |
- | exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor
| |
- | in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur
| |
- | sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum</p>
| |
- | <p>Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod <img class="figure" src="https://googledrive.com/host/0B4ZBZOYYKBzESTd1bnpoX0hWNzA"/><p class="caption">This is a caption</p><p>tempor
| |
- | incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud
| |
- | exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor
| |
- | in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur
| |
- | sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum</p>
| |
- | </div>
| |
- |
| |
- | <div class="hero-unit" id="text">
| |
- | <h4>Results 2</h4>
| |
- | <p>Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor
| |
- | incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud
| |
- | exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor
| |
- | in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur
| |
- | sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum</p><img class="figure" src="https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/FsZxKlaNDL/Screen%20shot%202013-05-31%20at%2015.29.53.png?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg"/>
| |
- | <p class="caption">This is a caption</p> <p>Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor
| |
- | incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud
| |
- | exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor
| |
- | in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur
| |
- | sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum</p>
| |
- | <img class="figure" src="https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/FsZxKlaNDL/Screen%20shot%202013-05-31%20at%2015.29.53.png?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg"/>
| |
- | <p class="caption">This is a caption</p><p>Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor
| |
- | incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud
| |
- | exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor
| |
- | in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur
| |
- | sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum</p>
| |
- | <p>Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor
| |
- | incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud
| |
- | exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor
| |
- | in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur
| |
- | sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum</p>
| |
- | <p>Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor
| |
- | incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud
| |
- | exercitation ullamco labori<img class="figure" src="https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/jtmF8YkJ_P/device%20photo.jpg?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg"/>
| |
- | <p class="caption">This is a caption</p><p>s nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor
| |
- | in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur
| |
- | sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum</p>
| |
- | <p>Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor
| |
- | incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud
| |
- | exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor
| |
- | in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur
| |
- | sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum</p>
| |
- | <p>Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor
| |
- | incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud
| |
- | exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor
| |
- | in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur
| |
- | sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum</p>
| |
- |
| |
- | </div>
| |
- |
| |
- | <div class="hero-unit" id="text">
| |
- | <h4>Results 3</h4>
| |
- | <p>Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor
| |
- | incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud
| |
- | exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor
| |
- | in <img class="figure" src="https://googledrive.com/host/0B4ZBZOYYKBzESTd1bnpoX0hWNzA"/><p class="caption">This is a caption</p><p>reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur
| |
- | sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum</p>
| |
- | <p>Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor
| |
- | incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud
| |
- | exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor
| |
- | in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur
| |
- | sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum</p>
| |
- | <p>Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor
| |
- | incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud
| |
- | exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor
| |
- | in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur
| |
- | sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum</p>
| |
- |
| |
- | </div>
| |
- |
| |
- | <div class="hero-unit" id="text">
| |
- | <h4>Results 4</h4>
| |
- | <p>Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor
| |
- | incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud
| |
- | exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor
| |
- | in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. <img class="figure" src="https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/jtmF8YkJ_P/device%20photo.jpg?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg"/>
| |
- | <p class="caption">This is a caption</p><p>Excepteur
| |
- | sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum</p>
| |
- | <p>Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor
| |
- | incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud
| |
- | exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor
| |
- | in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur
| |
- | sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum</p>
| |
- | </div>
| |
- |
| |
- | <div class="hero-unit" id="text">
| |
- | <h4>Results 5</h4>
| |
- | <p>Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor
| |
- | incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud
| |
- | exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor
| |
- | in reprehenderit in <img class="figure" src="https://dl.dropboxusercontent.com/sh/h4cxid18rzzjgan/FsZxKlaNDL/Screen%20shot%202013-05-31%20at%2015.29.53.png?token_hash=AAGlfzG2xZpKrOTI8pyH02EbYxY1vK3QLUWKsWuYdaPbYg"/>
| |
- | <p class="caption">This is a caption</p><p>voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur
| |
- | sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum</p>
| |
- | <p>Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor</p>
| |
- |
| |
- |
| |
- | </div>
| |
- |
| |
| | | |
| | | |
Abstract
The code of life is much more than a sequence of A's, G's, C's and T's;
a suite of epigenetic mechanisms, ranging from chromatin remodeling to non-coding RNAs,
affect gene expression and cellular function.
In particular, DNA methylation has been
shown to alter transcriptional activity in a powerful, heritable manner. Abnormal methylation
patterns are associated with diseases including immunodeficiency syndromes, neurodevelopmental
disorders, and many types of cancer. Comprehensive understanding and control of DNA methylation
could be invaluable to researchers studying these diseases.
Synthetic biologists and geneticists are accustomed to turning genes on and off at will,
but the tools don’t exist to easily manipulate epigenetic patterns. We are developing a novel
fusion protein that enables site-specific methylation, which can repress promoter activity with
high precision.
In coming years, this fusion protein could become a powerful tool for epigenetics
researchers looking to perform on/off studies in the vein of classical genetics, as well as an
orthogonal mode of repressing constitutive promoters for bacterial synthetic biologists.
Eventually, it could even give clinical researchers the means to restore healthy methylation
levels in many insofar-untreatable epigenetic diseases.