Team:Valencia Biocampus/Modeling

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Revision as of 10:49, 13 August 2013

Modeling

The main goal in our modelling project is to predict accurately the behaviour of our system in several issues, from the mounting of bacteria on C. elegans to the performance of our worms reaching the place of interest. In order to do that, we use several modelling techniques.

Biobricks modeling

Modeling of the biobricks performance

Chemotaxis

When no chemotactic source is present, C. elegans moves randomly. This behaviour can be modeled as a random walk (Berg,1993) and can be simulated in several steps using a programming language as Matlab. The equations of this model are the following:

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In presence of a chemotactic source,C. elegans moves in a similiar fashion as E. coli (Bangmann, 2006), a mechanism called the pirouette model (Pierce-Shimomura et al., 1999).

Bangmann CI (2006) Chemosensation in C. elegans. Wormbook
Berg HC (1993) Random walks in biology. Princeton, NJ: Princeton UP.
Pierce-Shimomura JT, Morse TM, Lockery SR (1999) The Fundamental Role of Pirouettes in C. elegans Chemotaxis. The journal of Neuroscience, 19(21):9557-9569

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 When no chemotactic source is present, <i>C. elegans</i> moves randomly. This behaviour can be modeled as a random walk (Berg,1993) and can be simulated in several steps using a programming language as <i>Matlab</i>. The equations of this model are the following:
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 <br>In presence of a chemotactic source,<i>C. elegans</i> moves in a similiar fashion as <i>E. coli</i> (Bangmann, 2006), a mechanism called <i>the pirouette model</i> (Pierce-Shimomura <i>et al.</i>, 1999).