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Team:Bonn
From 2013.igem.org
Regulating protein activity is important throughout lifescience research. Even though there are several systems available for regulation of proteins all suffer from certain disadvantages.
Aiming to overcome all of these drawbacks we engineer a novel system for light dependend regulation of protein degradation resulting in a rapid change of protein activity.
Our system can be not only of great importance for fundamental science to investigate protein function but also for accurate control of bioreactors and biological machines.
Project
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Background
To enable protein degradation we decided on one proteases system (ClpXP), which allows specific degradation of proteins, is highly conserved and well established.
For light dependency we compared several systems to finally find the best suited one. We created a comprehensive overview of all systems making artificially light control possible so that everyone can easily choose the optimal system for his approach.
Find out more about
the ClpXP protease System
our Comparison of several light sensitive systems
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Human Practice
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Team
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